Platelets—blood cells continuously produced from megakaryocytes mainly in the bone
marrow—are implicated not only in haemostasis and arterial thrombosis, but also in other …

Collagen, an extracellular protein, covers the entire human body and has several important
biological functions in normal physiology. Recently, collagen from non-human sources has …

Upon vascular injury, platelets are activated by adhesion to adhesive proteins, such as von
Willebrand factor and collagen, or by soluble platelet agonists, such as ADP, thrombin, and …

Platelets in a thrombus interact with (anti) coagulation factors and support blood
coagulation. In the concept of cell‐based control of coagulation, three different roles of …

Platelets have a crucial role in haemostasis and atherothrombosis. Pharmacological control
of platelet hyper-reactivity has become a cornerstone in the prevention of thrombo …

The role of platelets in hemostasis and thrombosis is dependent on a complex balance of
activatory and inhibitory signaling pathways. Inhibitory signals released from the healthy …

Blood platelets are anucleated circulating cells that play a critical role in hemostasis and are
also implicated in arterial thrombosis, a major cause of death worldwide. The biological …

Summary The glycoprotein VI (GPVI)–FcR γ‐chain complex initiates powerful activation of
platelets by the subendothelial matrix proteins collagen and laminin through an …

Abstract Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate important
intracellular signalling and vesicle trafficking events via the generation of 3 …

Custom-made and commercial parallel-plate flow chambers are widely used for studies of
platelet activation and thrombus formation in whole blood at defined shear rates. When used …