This review examines the generation of reactive oxygen species by mammalian
mitochondria, and the status of different sites of production in redox signaling and pathology …

Transition metals, such as iron, copper, and zinc, play a very important role in life as the
regulators of various physiochemical reactions in cells. Abnormal distribution and …

The identification of key genes in transcriptomic data constitutes a huge challenge. Our
review of microarray reports revealed 88 genes whose transcription is consistently regulated …

Copper is a transition metal that has been linked to pathological and beneficial effects in
neurodegenerative diseases. In Parkinson's disease, free copper is related to increased …

The cellular consequences of deficiencies of the mitochondrial OXPHOS system include a
variety of direct and secondary changes in metabolite homeostasis, such as ROS, Ca2+ …

The present study examines the pattern of accumulation of cadmium (Cd) and its
biochemical effects on selected tissues of a variety of African catfish (Clarias gariepinus) …

Oridonin, a bioactive diterpenoid isolated from Rabdosia rubescens, has been reported to
have anti-tumor effects, while the epidermal growth factor receptor (EGFR) signal pathway …

Little is known about the potential threats of silver nanoparticles (AgNPs) to ecosystem
health, with no detailed report existing on the stress and immune responses of soil …

Oridonin, a diterpenoid isolated from Rabdosia rubescences, could induce apoptosis
through the generation of reactive oxygen species (ROS) in human hepatoma HepG2 cells …

Metallothionein (MT) is a low molecular weight protein with anti-apoptotic properties that has
been demonstrated to scavenge free radicals in vitro. MT has not been extensively …