Anxiety disorders constitute a sizeable worldwide health burden with profound social and
economic consequences. The symptoms are wide-ranging; from hyperarousal to difficulties …

Prepulse inhibition (PPI) is a robust operational measure of sensorimotor gating. In
schizophrenic patients PPI is deficient. The aim of our review was to investigate the state of …

Introduction Under specific conditions, a weak lead stimulus, or “prepulse”, can inhibit the
startling effects of a subsequent intense abrupt stimulus. This startle-inhibiting effect of the …

Our 1992 paper,'The neural substrates of sensorimotor gating of the startle reflex: a review of
recent findings and their implications', reviewed a series of (then) new and preliminary …

Tourette syndrome (TS) is characterized by tics, sensorimotor gating deficiencies, and
abnormalities of cortico-basal ganglia circuits. A mutation in histidine decarboxylase (Hdc) …

In this article, we develop a computational model of obsessive–compulsive disorder (OCD).
We propose that OCD is characterized by a difficulty in relying on past events to predict the …

Functional and structural imaging studies suggest that obsessive–compulsive disorder
(OCD) symptoms arise from dysfunction in cortico-striato-thalamo-cortical circuits. It has …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that represents the
most common cause of dementia in the United States. Although the link between alcohol …

Prepulse Inhibition (PPI) of startle is an operational measure of the pre-attentive filtering
process known as sensorimotor gating. Originally identified in patients with schizophrenia …

Behavioral phenoty** has been gaining prominence due to the increased use of
transgenic animal models of neurological disorders. Repeated testing in the same cohort of …