Artificial intelligence and machine learning assisted drug delivery for effective treatment of infectious diseases
In the era of antimicrobial resistance, the prevalence of multidrug-resistant microorganisms
that resist conventional antibiotic treatment has steadily increased. Thus, it is now …
that resist conventional antibiotic treatment has steadily increased. Thus, it is now …
Broadly neutralizing antibodies for HIV-1 prevention
SR Walsh, MS Seaman - Frontiers in immunology, 2021 - frontiersin.org
Given the absence of an effective vaccine for protection against HIV-1 infection, passive
immunization strategies that utilize potent broadly neutralizing antibodies (bnAbs) to block …
immunization strategies that utilize potent broadly neutralizing antibodies (bnAbs) to block …
Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity
M Rosás-Umbert, JD Gunst, MH Pahus… - Nature …, 2022 - nature.com
In simian-human immunodeficiency virus (SHIV)-infected non-human primates, broadly
neutralizing antibodies (bNAbs) against the virus appear to stimulate T cell immunity. To …
neutralizing antibodies (bNAbs) against the virus appear to stimulate T cell immunity. To …
Antibody-mediated prevention and treatment of HIV-1 infection
H Gruell, F Klein - Retrovirology, 2018 - Springer
Novel broadly neutralizing antibodies targeting HIV-1 hold promise for their use in the
prevention and treatment of HIV-1 infection. Pre-clinical results have encouraged the …
prevention and treatment of HIV-1 infection. Pre-clinical results have encouraged the …
Broadly neutralizing antibodies for HIV-1 prevention and therapy
B Julg, D Barouch - Seminars in Immunology, 2021 - Elsevier
Despite immense progress in our ability to prevent and treat HIV-1 infection, HIV-1 remains
an incurable disease and a highly efficacious HIV-1 vaccine is not yet available. Additional …
an incurable disease and a highly efficacious HIV-1 vaccine is not yet available. Additional …
Broadly neutralizing antibodies against HIV-1 and concepts for application
Highlights•Broadly neutralizing antibodies are promising for HIV-1 prevention and
therapy.•Newly identified bNAbs reveal novel epitopes and binding modes.•Effective …
therapy.•Newly identified bNAbs reveal novel epitopes and binding modes.•Effective …
[HTML][HTML] Improved HIV-1 neutralization breadth and potency of V2-apex antibodies by in silico design
Broadly neutralizing antibodies (bNAbs) against HIV can reduce viral transmission in
humans, but an effective therapeutic will require unusually high breadth and potency of …
humans, but an effective therapeutic will require unusually high breadth and potency of …
Machine-learning-assisted high-throughput identification of potent and stable neutralizing antibodies against all four dengue virus serotypes
Several computational methods have been developed to identify neutralizing antibodies
(NAbs) covering four dengue virus serotypes (DENV-1 to DENV-4); however, limitations of …
(NAbs) covering four dengue virus serotypes (DENV-1 to DENV-4); however, limitations of …
Prediction of HIV sensitivity to monoclonal antibodies using aminoacid sequences and deep learning
VR Dănăilă, C Buiu - Bioinformatics, 2022 - academic.oup.com
Motivation Knowing the sensitivity of a viral strain versus a monoclonal antibody is of interest
for HIV vaccine development and therapy. The HIV strains vary in their resistance to …
for HIV vaccine development and therapy. The HIV strains vary in their resistance to …
[HTML][HTML] The applications of machine learning in HIV neutralizing antibodies research—A systematic review
VR Dănăilă, S Avram, C Buiu - Artificial Intelligence in Medicine, 2022 - Elsevier
Abstract Machine learning algorithms play an essential role in bioinformatics and allow
exploring the vast and noisy biological data in unrivaled ways. This paper is a systematic …
exploring the vast and noisy biological data in unrivaled ways. This paper is a systematic …