[HTML][HTML] Pharmacogenomics: A genetic approach to drug development and therapy
The majority of the well-known pharmacogenomics research used in the medical sciences
contributes to our understanding of medication interactions. It has a significant impact on …
contributes to our understanding of medication interactions. It has a significant impact on …
Deciphering molecular landscape of breast cancer progression and insights from functional genomics and therapeutic explorations followed by in vitro validation
Breast cancer is caused by aberrant breast cells that proliferate and develop into tumors.
Tumors have the potential to spread throughout the body and become lethal if ignored …
Tumors have the potential to spread throughout the body and become lethal if ignored …
[PDF][PDF] Systems-level understanding of toxicology and cardiovascular system
S Almowallad, R Jeet, M Mobashir - Jour. Bas. Sci, 2024 - researchgate.net
The extensive networks of molecular and functional alterations that take place at many
levels of biological structure are studied using traditional toxicology and quantitative …
levels of biological structure are studied using traditional toxicology and quantitative …
An approach for systems-level understanding of prostate cancer from high-throughput data integration to pathway modeling and simulation
To understand complex diseases, high-throughput data are generated at large and multiple
levels. However, extracting meaningful information from large datasets for comprehensive …
levels. However, extracting meaningful information from large datasets for comprehensive …
Construction and validation of a novel cuproptosis-mitochondrion prognostic model related with tumor immunity in osteosarcoma
J Feng, J Wang, Y Xu, F Lu, J Zhang, X Han, C Zhang… - Plos one, 2023 - journals.plos.org
Background The purpose of this study was to develop a new prognostic model for
osteosarcoma based on cuproptosis-mitochondrion genes. Materials and methods The data …
osteosarcoma based on cuproptosis-mitochondrion genes. Materials and methods The data …
Impact of curcumin on ferroptosis‐related genes in colorectal cancer: Insights from in‐silico and in‐vitro studies
Colorectal cancer (CRC) is responsible for a significant number of cancer‐related fatalities
worldwide. Researchers are investigating the therapeutic potential of ferroptosis, a type of …
worldwide. Researchers are investigating the therapeutic potential of ferroptosis, a type of …
Genomic profiling and network-level understanding uncover the potential genes and the pathways in hepatocellular carcinoma
Data integration with phenotypes such as gene expression, pathways or function, and
protein-protein interactions data has proven to be a highly promising technique for …
protein-protein interactions data has proven to be a highly promising technique for …
Multi-omics analysis uncovers clinical, immunological, and pharmacogenomic implications of cuproptosis in clear cell renal cell carcinoma
M Zhu, Y Li, Y Wang, P Lin, J Mi, W Zhong - European Journal of Medical …, 2023 - Springer
Objective The latest research proposed a novel copper-dependent programmed cell death
named cuproptosis. We aimed to elucidate the influence of cuproptosis in clear cell renal …
named cuproptosis. We aimed to elucidate the influence of cuproptosis in clear cell renal …
Predicting congenital renal tract malformation genes using machine learning
Congenital renal tract malformations (RTMs) are the major cause of severe kidney failure in
children. Studies to date have identified defined genetic causes for only a minority of human …
children. Studies to date have identified defined genetic causes for only a minority of human …
The cuproptosis related genes signature predicts the prognosis and correlates with the immune status of clear cell renal cell carcinoma
P Sun, H Xu, K Zhu, M Li, R Han, J Shen, X **a… - Frontiers in …, 2022 - frontiersin.org
Background: Clear cell renal cell carcinoma (CCRCC) has a high incidence and poor
prognosis. Cuproptosis, an independent pattern of cell death associated with copper, plays …
prognosis. Cuproptosis, an independent pattern of cell death associated with copper, plays …