Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT
receptor has been discovered and there is little evidence that this situation will change in the …

The hippocampus is a crucial brain region involved in the process of forming and
consolidating memories. Memories are consolidated in the brain through synaptic plasticity …

Major depressive disorder is a devastating psychiatric disease that afflicts up to 17% of the
world's population. Postmortem brain analyses and imaging studies of patients with …

Cholecystokinin (CCK) plays a key role in various brain functions, including both health and
disease states. Despite the extensive research conducted on CCK, there remain several …

Cholinergic interneurons (ChIs) in the nucleus accumbens (NAc) have been implicated in
drug addiction, reward, and mood disorders. However, the physiological role of ChIs in …

Abstract Serotonin receptor 4 (5-HT4R) plays an important role in regulating mood, anxiety,
and cognition, and drugs that activate this receptor have fast-acting antidepressant (AD)-like …

Stress can cause a variety of central nervous system disorders, which are critically mediated
by the γ‐aminobutyric acid (GABA) system in various brain structures. GABAergic neurons …

p11 (S100A10, annexin II light chain, calpactin I light chain) is a multifunctional protein that
forms a heterotetrameric complex with Annexin A2, particularly at cell membranes. p11 …

Depressive-like behavior is a highly prevalent worldwide neuropsychiatric disorder that
owns a complex pathophysiologic mechanism. The available pharmacotherapy is ineffective …

Background The dentate gyrus (DG) has been implicated in the pathophysiology of
depression. Many studies have revealed the cellular types, neural circuits, and …