Mendelian randomization

E Sanderson, MM Glymour, MV Holmes… - Nature Reviews …, 2022 - nature.com
Mendelian randomization (MR) is a term that applies to the use of genetic variation to
address causal questions about how modifiable exposures influence different outcomes …

Misinformation in and about science

JD West, CT Bergstrom - Proceedings of the National …, 2021 - National Acad Sciences
Humans learn about the world by collectively acquiring information, filtering it, and sharing
what we know. Misinformation undermines this process. The repercussions are extensive …

Participation bias in the UK Biobank distorts genetic associations and downstream analyses

T Schoeler, D Speed, E Porcu, N Pirastu… - Nature Human …, 2023 - nature.com
While volunteer-based studies such as the UK Biobank have become the cornerstone of
genetic epidemiology, the participating individuals are rarely representative of their target …

Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial

M Ezpeleta, K Gabel, S Cienfuegos, F Kalam, S Lin… - Cell metabolism, 2023 - cell.com
Innovative non-pharmacological lifestyle strategies to treat non-alcoholic fatty liver disease
(NAFLD) are critically needed. This study compared the effects of alternate day fasting (ADF) …

Socioeconomic status and child psychopathology in the United States: A meta-analysis of population-based studies

M Peverill, MA Dirks, T Narvaja, KL Herts… - Clinical psychology …, 2021 - Elsevier
Children raised in families with low socioeconomic status (SES) are more likely to exhibit
symptoms of psychopathology. However, the strength of this association, the specific indices …

[HTML][HTML] Using genetic association data to guide drug discovery and development: review of methods and applications

S Burgess, AM Mason, AJ Grant, EAW Slob… - The American Journal of …, 2023 - cell.com
Evidence on the validity of drug targets from randomized trials is reliable but typically
expensive and slow to obtain. In contrast, evidence from conventional observational …

On the need for a language describing distribution shifts: Illustrations on tabular datasets

J Liu, T Wang, P Cui… - Advances in Neural …, 2024 - proceedings.neurips.cc
Different distribution shifts require different algorithmic and operational interventions.
Methodological research must be grounded by the specific shifts they address. Although …

[HTML][HTML] Dietary fiber, atherosclerosis, and cardiovascular disease

GA Soliman - Nutrients, 2019 - mdpi.com
Background: Open Access Communication Dietary Fiber, Atherosclerosis, and
Cardiovascular Disease by Ghada A. Soliman Department of Environmental, Occupational …

Multivariable Mendelian randomization and mediation

E Sanderson - Cold Spring Harbor perspectives …, 2021 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is the use of genetic variants associated with an exposure to
estimate the causal effect of that exposure on an outcome. Mediation analysis is the method …

Healthy lifestyle and life expectancy in people with multimorbidity in the UK Biobank: a longitudinal cohort study

YV Chudasama, K Khunti, CL Gillies… - PLoS …, 2020 - journals.plos.org
Background Whether a healthy lifestyle impacts longevity in the presence of multimorbidity is
unclear. We investigated the associations between healthy lifestyle and life expectancy in …