Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …

Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

Schizophrenia is a disorder with a heterogeneous etiology involving complex interplay
between genetic and environmental risk factors. The immune system is now known to play …

Mitochondria retain bacterial traits due to their endosymbiotic origin, but host cells do not
recognize them as foreign because the organelles are sequestered. However, the regulated …

The accumulation of DNA and nuclear components in blood and their recognition by
autoantibodies play a central role in the pathophysiology of systemic lupus erythematosus …

Systemic lupus erythematosus (SLE) is a genetically predisposed, female-predominant
disease, characterized by multiple organ damage, that in its most severe forms can be life …

In addition to their hemostatic role, platelets play a significant role in immunity. Once
activated, platelets release extracellular vesicles (EVs) formed by the budding of their …

The mitochondrion is an intracellular organelle thought to originate from endosymbiosis
between an ancestral eukaryotic cell and an α-proteobacterium. Mitochondria are the …

Mitochondria participate in a wide range of cellular processes. One essential function of
mitochondria is to be a platform for antiviral signaling proteins during the innate immune …

Tricarboxylic acid (TCA) cycle metabolites have been implicated in modulating signalling
pathways in immune cells. Notable examples include succinate and itaconate, which have …