Mendelian randomization: concepts and scope
RC Richmond, GD Smith - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
A meta‐review of “lifestyle psychiatry”: the role of exercise, smoking, diet and sleep in the prevention and treatment of mental disorders
There is increasing academic and clinical interest in how “lifestyle factors” traditionally
associated with physical health may also relate to mental health and psychological well …
associated with physical health may also relate to mental health and psychological well …
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …
mood and anhedonia. Depression has a heritable component that has remained difficult to …
The association of cigarette smoking with depression and anxiety: a systematic review
Background: Many studies report a positive association between smoking and mental
illness. However, the literature remains mixed regarding the direction of this association. We …
illness. However, the literature remains mixed regarding the direction of this association. We …
Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study
BackgroundSmoking prevalence is higher amongst individuals with schizophrenia and
depression compared with the general population. Mendelian randomisation (MR) can …
depression compared with the general population. Mendelian randomisation (MR) can …
Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study
Objectives To identify the genetic determinants of fracture risk and assess the role of 15
clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide …
clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide …
Genetics of substance use disorders in the era of big data
Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …
substances, such as nicotine, alcohol or opioids, results in clinical and functional …
Statistical and integrative system-level analysis of DNA methylation data
Epigenetics plays a key role in cellular development and function. Alterations to the
epigenome are thought to capture and mediate the effects of genetic and environmental risk …
epigenome are thought to capture and mediate the effects of genetic and environmental risk …
Map** risk factors for depression across the lifespan: an umbrella review of evidence from meta-analyses and Mendelian randomization studies
The development of depression may involve a complex interplay of environmental and
genetic risk factors. PubMed and PsycInfo databases were searched from inception through …
genetic risk factors. PubMed and PsycInfo databases were searched from inception through …
Clinical guidelines for the use of lifestyle-based mental health care in major depressive disorder: World Federation of Societies for Biological Psychiatry (WFSBP) and …
W Marx, SH Manger, M Blencowe… - The World Journal of …, 2023 - Taylor & Francis
Objectives The primary objectives of these international guidelines were to provide a global
audience of clinicians with (a) a series of evidence-based recommendations for the …
audience of clinicians with (a) a series of evidence-based recommendations for the …