The placenta sits at the interface between the maternal and fetal vascular beds where it
mediates nutrient and waste exchange to enable in utero existence. Placental cells …

Proper placental development and function are central to the health of both the mother and
the fetus during pregnancy. A critical component of healthy placental function is the proper …

Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of
maternal and perinatal death. The causes of preeclampsia remain unclear, but there is …

Preeclampsia is a pregnancy-specific disorder, of which one of its major subtypes, the
placental subtype is considered a response to an ischemic placental environment, impacting …

The pregnancy complication preeclampsia (PE), which occurs in approximately 3% to 8% of
human pregnancies, is characterized by placental pathologies that can lead to significant …

Hypertensive disorders are life-threatening diseases with high morbidity and mortality,
affecting billions of individuals worldwide. A multitude of underlying conditions may …

Rana et al Angiogenic Factors and Preeclampsia 199 including those who remain
normotensive. 4, 15 These factors combined with the above discussed physiological …

Mammalian pregnancy involves tremendous de novo maternal vascular construction to
adequately support conceptus development. In early mouse decidua basalis (DB), maternal …

Background Pre-eclampsia is a multifactorial hypertensive disorder that is triggered by
placental insufficiency and that accounts for up to 15% of maternal deaths. In normal …

Breakdown of blood-brain barrier (BBB) represents a key pathology in hyperglycemia-
mediated cerebrovascular damage after an ischemic stroke. As changes in the level and …