The many biological and biomedical effects of selenium are relatively unknown outside the
selenium field. This fascinating element, initially described as a toxin, was subsequently …

In humans, selenium was hypothesized to lower the risk of several chronic diseases, mainly
due to the antioxidant activity of selenium-containing proteins. Recent epidemiologic and …

Selenium (Se) is essential for human health, however, Se is deficient in soil in many places
all around the world, resulting in human diseases, such as notorious Keshan disease and …

Background The most important health benefit of selenium (Se) is in the prevention and
control of cancer. Glutathione peroxidases (GPXs) and thioredoxin reductases (TXNRDs) …

The critical importance of glutathione in mitigating the deleterious effects of electrophile
generating drugs such as acetaminophen (APAP) is well established. However, the role of …

Abstract Thioredoxin reductase 1 (TR1) controls the redox state of protein thiols in
mammalian cells and has been shown to have roles in both preventing and promoting …

Selenium deficiency is known to increase cancer risk by so far unclear mechanisms.
Selenium exerts its biological effects via selenocysteine as an integral part of …

Selenoproteins mediate much of the cancer-preventive properties of the essential nutrient
selenium, but some of these proteins have been shown to also have cancer-promoting …

Background: Available studies on the effect of serum selenium levels on the risk of
malignancies show some conflicting results. In this study, we investigated the correlation …

Individuals exposed to fibrogenic mineral dust may exhibit an impaired antioxidant system
and produce high levels of reactive oxygen and nitrogen species through immune cells …