The field of vascular biology has gained enormous insight from the use of Cre and inducible
Cre mouse models to temporally and spatially manipulate gene expression within the …

The cre‐loxP–mediated recombination system (the “cre‐loxP system”) is an integral
experimental tool for mammalian genetics and cell biology. Use of the system has greatly …

Neuronal activity is crucial for adaptive circuit remodelling but poses an inherent risk to the
stability of the genome across the long lifespan of postmitotic neurons,,,–. Whether neurons …

DNA methylation (DNAme) is a key epigenetic mark that regulates critical biological
processes maintaining overall genome stability. Given its pleiotropic function, studies of …

Breast cancer is not a single disease, but is instead a collection of diseases that have
distinct histopathological features, genetic and genomic variability, and diverse prognostic …

Site-specific recombinase systems (Cre-loxP, Flp-FRT, and φC31-att) are transforming both
forward and reverse genetics in mice. By enabling high-fidelity DNA modifications to be …

Activating mutations in the ras oncogene are not considered sufficient to induce abnormal
cellular proliferation in the absence of cooperating oncogenes. We demonstrate that the …

Animal models of cancer provide an alternative means to determine the causes of and
treatments for malignancy, thus representing a resource of immense potential for cancer …

Transgenesis has been a mainstay of mouse genetics for over 30 yr, providing numerous
models of human disease and critical genetic tools in widespread use today. Generated …

Summary Cx3cr1 CreER-driven Cre recombinase (Cre) is a widely used genetic tool for
enabling gene manipulation in microglia and macrophages. However, an in-depth analysis …