Since the introduction of insulin almost a century ago, more than 80 peptide drugs have
reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis …

Voltage-gated ion channels (VGICs), including those for Na+, Ca2+ and K+, selectively
permeate ions across the cell membrane in response to changes in membrane potential …

Voltage-gated sodium (Nav) channels are targeted by a number of widely used and
investigational drugs for the treatment of epilepsy, arrhythmia, pain, and other disorders …

The neuronal-type (N-type) voltage-gated calcium (Cav) channels, which are designated
Cav2. 2, have an important role in the release of neurotransmitters,–. Ziconotide is a Cav2. 2 …

The dorsal root ganglia–localized voltage-gated sodium (Nav) channel Nav1. 8 represents a
promising target for develo** next-generation analgesics. A prominent characteristic of …

Analyses of publicly available structural data reveal interesting insights into the impact of the
three‐dimensional (3D) structures of protein targets important for discovery of new drugs …

Voltage-gated sodium channel Na v 1.5 generates cardiac action potentials and initiates the
heartbeat. Here, we report structures of Na V 1.5 at 3.2–3.5 Å resolution. Na V 1.5 is …

Voltage-gated sodium channel Nav1. 6 plays a crucial role in neuronal firing in the central
nervous system (CNS). Aberrant function of Nav1. 6 may lead to epilepsy and other …

The L-type voltage-gated Ca 2+(Ca v) channels are modulated by various compounds
exemplified by 1, 4-dihydropyridines (DHP), benzothiazepines (BTZ), and …

Voltage-gated sodium and calcium channels are evolutionarily related transmembrane
signaling proteins that initiate action potentials, neurotransmission, excitation-contraction …