Resurrection of 2′-5′-oligoadenylate synthetase 1 (OAS1) from the ancestor of modern horseshoe bats blocks SARS-CoV-2 replication

S Lytras, A Wickenhagen, E Sugrue, DG Stewart… - Plos …, 2023 - journals.plos.org
The prenylated form of the human 2′-5′-oligoadenylate synthetase 1 (OAS1) protein has
been shown to potently inhibit the replication of Severe Acute Respiratory Syndrome …

Genomic transfers help to decipher the ancient evolution of filoviruses and interactions with vertebrate hosts

DJ Taylor, MH Barnhart - PLoS pathogens, 2024 - journals.plos.org
Although several filoviruses are dangerous human pathogens, there is conflicting evidence
regarding their origins and interactions with animal hosts. Here we attempt to improve this …

Endogenous viral elements: insights into data availability and accessibility

M Ritsch, N Brait, E Harvey, M Marz… - Virus Evolution, 2024 - academic.oup.com
Endogenous viral elements (EVEs) are remnants of viral genetic material endogenized into
the host genome. They have, in the last decades, attracted attention for their role as potential …

Evolution of the Cytomegalovirus RL11 gene family in Old World monkeys and Great Apes

U Litvin, ECY Wang, RJ Stanton, CA Fielding… - Virus …, 2024 - academic.oup.com
Cytomegalovirus (CMV) is a genus of herpesviruses, members of which share a long history
of coevolution with their primate hosts including New World monkeys, Old World monkeys …

Exploring the role of endogenous retroviruses in seasonal reproductive cycles: a case study of the ERV-V envelope gene in mink

Y Zhang, G Wang, Y Zhu, X Cao, F Liu, H Li… - Frontiers in Cellular and …, 2024 - frontiersin.org
Introduction Endogenous retroviruses (ERVs), which originated from exogenous retroviral
infections of germline cells millions of years ago and were inherited by subsequent …

Endogenous Bornavirus-like Elements in Bats: Evolutionary Insights from the Conserved Riboviral L-Gene in Microbats and Its Antisense Transcription in Myotis …

M Ritsch, T Eulenfeld, K Lamkiewicz, A Schoen… - …, 2024 - pmc.ncbi.nlm.nih.gov
Bats are ecologically diverse vertebrates characterized by their ability to host a wide range
of viruses without apparent illness and the presence of numerous endogenous viral …

Mutational Constraint Analysis Workflow for Overlap** Short Open Reading Frames and Genomic Neighbours

M Danner, M Begemann, F Kraft, M Elbracht, I Kurth… - bioRxiv, 2024 - biorxiv.org
Understanding the dark genome is a priority task following the complete sequencing of the
human genome. Short open reading frames (sORFs) are a group of largely unexplored …

detectEVE: fast, sensitive and precise detection of endogenous viral elements in genomic data

N Brait, T Hackl, S Lequime - bioRxiv, 2024 - biorxiv.org
Endogenous viral elements (EVEs) are fragments of viral genomic material embedded
within the host genome. Retroviruses contribute to the majority of EVEs due to their genomic …