Synchronous, rhythmic changes in the membrane polarization of neurons form oscillations
in local field potentials. It is hypothesized that high-frequency brain oscillations reflect local …

Functional evaluation assays using human induced pluripotent stem cell (hiPSC)-derived
neurons can predict the convulsion toxicity of new drugs and the neurological effects of …

Background Phase-amplitude coupling (PAC) in which the amplitude of a faster field
potential oscillation is coupled to the phase of a slower rhythm, is one of the most well …

Epilepsy is a network disease caused by aberrant neocortical large-scale connectivity
spanning regions on the scale of several centimeters. High-frequency oscillations …

Background Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy.
Recent studies have demonstrated that ultrasound stimulation can inhibit spontaneous …

Objective Reliable localization of the epileptogenic zone is necessary for successful
epilepsy surgery. Neurophysiological biomarkers include ictal onsets and interictal spikes …

Objective. Diagnosing epilepsy still requires visual interpretation of electroencephalography
(EEG) and magnetoencephalography (MEG) by specialists, which prevents quantification …

Amongst the numerous genes associated with intellectual disability, SYNGAP1 stands out
for its frequency and penetrance of loss-of-function variants found in patients, as well as the …

Polyrhythmic coupling of oscillatory components in electrophysiological signals results from
the interactions between neuronal sub-populations within and between cell assemblies …

Objective Drug‐resistant focal epilepsy is widely recognized as a network disease in which
epileptic seizure propagation is likely coordinated by different neuronal oscillations such as …