Viruses that replicate in the human respiratory mucosa without infecting systemically,
including influenza A, SARS-CoV-2, endemic coronaviruses, RSV, and many other" …

Vaccines based on historical virus isolates provide limited protection from continuously
evolving RNA viruses, such as influenza viruses or coronaviruses, which occasionally spill …

Aptameric receptors are important biosensor components, yet our ability to identify them
depends on the target structures. We analyzed the contributions of individual functional …

B cell responses are critical for antiviral immunity. However, a comprehensive picture of
antigen-specific B cell differentiation, clonal proliferation, and dynamics in different organs …

Influenza viruses remain a severe burden to human health because of their contribution to
overall morbidity and mortality. Current seasonal influenza virus vaccines do not provide …

Cell fate decisions during early B cell activation determine the outcome of responses to
pathogens and vaccines. We examined the early B cell response to T-dependent antigen in …

Improved influenza vaccines are urgently needed to reduce the burden of seasonal
influenza and to ensure a rapid and effective public-health response to future influenza …

Human broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin stalk of group 1
influenza A viruses (IAVs) are biased for IGHV1-69 alleles that use phenylalanine (F54) but …

Broadly neutralizing antibodies are critical for protection against both drifted and shifted
influenza viruses. Here, we reveal that first exposure to the 2009 pandemic H1N1 influenza …

Polyreactivity is the ability of a single antibody to bind to multiple molecularly distinct
antigens and is a common feature of antibodies induced upon pathogen exposure …