Adenosine diphosphate (ADP)-ribosylation is an important posttranslational modification
catalyzed by a variety of enzymes, including poly (ADP ribose) polymerases (PARPs), which …

Arsenic is a ubiquitous environmental contaminant that exists in many inorganic and organic
forms. In particular, arsenite is known to induce immunotoxicity in humans and animals …

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear enzyme in
mammalian cells. The enzyme synthesizes polymers of ADP-ribose from the coenzyme …

Abstract Treatment of base excision repair–proficient mouse fibroblasts with the DNA
alkylating agent methyl methanesulfonate (MMS) and a small molecule inhibitor of PARP-1 …

BACKGROUND AND PURPOSE: Current therapies for head and neck cancer frequently are
not curative, necessitating novel therapeutic strategies. Thus, we studied whether inhibition …

Poly (ADP-ribose)(PAR) is a negatively charged polymer that is biosynthesized by Poly
(ADP-ribose) Polymerase-1 (PARP-1) and regulates various cellular processes. Alpha …

The combination of poly (ADP-ribose) polymerase (PARP) inhibitors and alkylating agents is
currently being investigated in cancer therapy clinical trials. However, the DNA lesions …

Arsenic trioxide (ATO) is successfully used to treat hematological malignancies. However,
the clinical application of the agent in solid tumors is largely limited by its dose-dependent …

Base excision repair (BER) can protect a cell after endogenous or exogenous genotoxic
stress, and a deficiency in BER can render a cell hypersensitive to stress-induced apoptotic …

Novel targeted agents to inhibit DNA repair pathways to sensitize tumors to irradiation (IR)
are being investigated as an alternative to chemoradiation for locally advanced human …