Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial
ischemia with or without reperfusion, and basic and translational research is needed to …

The coronary circulation is both culprit and victim of acute myocardial infarction. The rupture
of an epicardial atherosclerotic plaque with superimposed thrombosis causes coronary …

Current therapy of advanced cancers is based on several modalities including radiotherapy,
cytotoxic chemotherapy, molecularly targeted inhibitors and antibodies targeting immune …

Vascular endothelial growth factors (VEGFs) have been shown to participate in
atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis …

The treatment of ocular neovascular diseases is being revolutionized by intravitreal
therapies targeting vascular endothelial growth factor (VEGF). Two agents are approved for …

Following an arterial occlusion outward remodeling of pre-existent inter-connecting
arterioles occurs by proliferation of vascular smooth muscle and endothelial cells. This is …

Normal high-density lipoprotein (nHDL) can induce angiogenesis in healthy individuals.
However, HDL from patients with coronary artery disease undergoes various modifications …

Substantial variability exists in collateral density and ischemia-induced collateral growth
among species. To begin to probe the underlying mechanisms, which are unknown, we …

Formation of arterial vasculature, here termed arteriogenesis, is a central process in
embryonic vascular development as well as in adult tissues. Although the process of …

The density of native (preexisting) collaterals and their capacity to enlarge into large conduit
arteries in ischemia (arteriogenesis) are major determinants of the severity of tissue injury in …