A global view of the interplay between non-alcoholic fatty liver disease and diabetes

N Stefan, K Cusi - The lancet Diabetes & endocrinology, 2022 - thelancet.com
Non-alcoholic fatty liver disease (NAFLD) has become an epidemic, much like other non-
communicable diseases (NCDs), such as cancer, obesity, diabetes, and cardiovascular …

The role of lipids in cancer progression and metastasis

M Martin-Perez, U Urdiroz-Urricelqui, C Bigas… - Cell metabolism, 2022 - cell.com
Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …

Lipid droplet biogenesis and functions in health and disease

A Zadoorian, X Du, H Yang - Nature Reviews Endocrinology, 2023 - nature.com
Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

DH Ipsen, J Lykkesfeldt, P Tveden-Nyborg - Cellular and molecular life …, 2018 - Springer
Non-alcoholic fatty liver disease (NAFLD) is currently the world's most common liver
disease, estimated to affect up to one-fourth of the population. Hallmarked by hepatic …

The role of hepatokines in NAFLD

N Stefan, F Schick, AL Birkenfeld, HU Häring, MF White - Cell metabolism, 2023 - cell.com
Non-alcoholic fatty liver disease (NAFLD) is not only a consequence of insulin resistance,
but it is also an important cause of insulin resistance and major non-communicable diseases …

[HTML][HTML] Western diet and the immune system: an inflammatory connection

A Christ, M Lauterbach, E Latz - Immunity, 2019 - cell.com
The consumption of Western-type calorically rich diets combined with chronic overnutrition
and a sedentary lifestyle in Western societies evokes a state of chronic metabolic …

Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy

JC Arroyave-Ospina, Z Wu, Y Geng, H Moshage - Antioxidants, 2021 - mdpi.com
Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …

[HTML][HTML] The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease

JN van der Veen, JP Kennelly, S Wan, JE Vance… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are the most abundant
phospholipids in all mammalian cell membranes. In the 1950s, Eugene Kennedy and co …

Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state

L Magtanong, PJ Ko, M To, JY Cao, GC Forcina… - Cell chemical …, 2019 - cell.com
The initiation and execution of cell death can be regulated by various lipids. How the levels
of environmental (exogenous) lipids impact cell death sensitivity is not well understood. We …

Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

P Rada, Á González-Rodríguez, C García-Monzón… - Cell death & …, 2020 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic …