Tuberous sclerosis complex is a rare genetic disease associated with mutations in the TSC1
or TSC2 genes, which cause overactivation of the mTOR complex. In the past 5 years …

Novel and effective antiseizure medications are needed to treat refractory and rare forms of
epilepsy. Cannabinoids, which are obtained from the cannabis plant, have a long history of …

Objective Epilepsy develops in 70 to 90% of children with tuberous sclerosis complex (TSC)
and is often resistant to medication. Recently, the concept of preventive antiepileptic …

Over the last decade, advances in genetics, neuroimaging and EEG have enabled the
aetiology of epilepsy to be identified earlier in the disease course than ever before. At the …

Lactate is used as an energy source by producer cells or shuttled to neighboring cells and
tissues. Both glucose and lactate fulfill the bioenergetic demand of neurons, the latter …

The mechanistic target of rapamycin (mTOR) pathway serves as a master regulator of cell
growth, proliferation, and survival. Upregulation of the mTOR pathway has been shown to …

Objective This review will summarize current knowledge on the burden of illness (BOI) in
tuberous sclerosis complex (TSC), a multisystem genetic disorder manifesting with …

Tuberous sclerosis complex (TSC) is a rare genetic disorder caused by mutations in the
TSC1 or TSC2 genes, which encode proteins that antagonise the mammalian isoform of the …

The mechanistic target of rapamycin (mTOR) is a kinase at the center of an evolutionarily
conserved signaling pathway that orchestrates cell growth and metabolism. mTOR responds …

Introduction: Individuals with Tuberous Sclerosis Complex (TSC) are at increased risk of
develo** both epilepsy and autism spectrum disorder (ASD), but the relationship between …