Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing

JK Joung, JD Sander, M Maeder, Y Fu - US Patent 9,567,604, 2017 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
51537665&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing

JK Joung, S Tsai - US Patent 9,567,603, 2017 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
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Increasing specificity for RNA-guided genome editing

JK Joung, J Angstman, JD Sander, M Maeder… - US Patent …, 2018 - Google Patents
US9885033B2 - Increasing specificity for RNA-guided genome editing - Google Patents
US9885033B2 - Increasing specificity for RNA-guided genome editing - Google Patents …

RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci

JK Joung, M Maeder - US Patent 10,760,064, 2020 - Google Patents
BACKGROUND Clustered Regulatory Interspaced Short Palindromic Repeats (CRISPR),
and CRISPR-associated (cas) genes, referred to as CRISPR/Cas systems, are used by …

Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing

JK Joung, JD Sander, Y Fu, M Maeder - US Patent 10,119,133, 2018 - Google Patents
CRISPR-Cas genome editing uses a guide RNA, which includes both a complementarity
region, which binds the target DNA by base-pairing, and a Cas9-binding region, to direct a …

Compositions and methods for protein production

XY Li, A Jamieson, V Bartsevich… - US Patent App. 11 …, 2006 - Google Patents
US20060063231A1 - Compositions and methods for protein production - Google Patents
US20060063231A1 - Compositions and methods for protein production - Google Patents …

Plasma whirl reactor apparatus and methods of use

TL Foret - US Patent 7,622,693, 2009 - Google Patents
Apparatus for synergistically combining a plasma with a comminution means such as a fluid
kinetic energy mill (jet mill), preferably in a single reactor and/or in a single process step is …

Amino lipids and methods for the delivery of nucleic acids

MJ Hope, SC Semple, J Chen, TD Madden… - US Patent …, 2015 - Google Patents
Related US Application Data Gong and Lin," A glassy carbon Supported bilayer lipid-like
mem brane of 5.5-diteradecyl-2-(2-trimethyl-ammonioethyl)-1, 3-(60) Provisional application …

RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci

JK Joung, M Maeder - US Patent 10,378,027, 2019 - Google Patents
US10378027B2 - RNA-guided targeting of genetic and epigenomic regulatory proteins to
specific genomic loci - Google Patents US10378027B2 - RNA-guided targeting of genetic …

Amino lipids and methods for the delivery of nucleic acids

MJ Hope, SC Semple, J Chen, TD Madden… - US Patent …, 2020 - Google Patents
US10653780B2 - Amino lipids and methods for the delivery of nucleic acids - Google
Patents US10653780B2 - Amino lipids and methods for the delivery of nucleic acids …