Ferroptosis is an iron‐dependent, oxidative form of non‐apoptotic cell death. This form of
cell death does not share morphological, biochemical, or genetic similarities with classic …

The normal function of poly (ADP-ribose) polymerase-1 (PARP-1) is the routine repair of
DNA damage by adding poly (ADP ribose) polymers in response to a variety of cellular …

Poly (ADP-ribosyl) ation (PARylation) is catalysed by poly (ADP-ribose) polymerases
(PARPs, also known as ARTDs) and then rapidly removed by degrading enzymes. Poly …

Poly (ADP-ribose) polymerase-1 (PARP-1) protects the genome by functioning in the DNA
damage surveillance network. PARP-1 is also a mediator of cell death after ischemia …

An early transient burst of poly (ADP-ribosyl) ation of nuclear proteins was recently shown to
be required for apoptosis to proceed in various cell lines (Simbulan-Rosenthal, C …

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is a member of the PARP enzyme family
consisting of PARP-1 and several recently identified novel poly (ADP-ribosylating) enzymes …

Biochemical modulation is the manipulation of cellular biochemical pathways by chemical
agents to produce selective enhancement of the efficacy of an antitumor drug. 1 Since the …

For a long time necrosis was considered as an alternative to programmed cell death,
apoptosis. Indeed, necrosis has distinct morphological features and it is accompanied by …

Poly (ADP-ribosylation) is a post-translational modification of proteins playing a crucial role
in many processes, including DNA repair and cell death. The best known poly (ADP …

Caspases are a large family of evolutionarily conserved proteases found from
Caenorhabditis elegans to humans. Although the first caspase was identified as a …