Contemporary issues in the surgical management of pleural mesothelioma

J Paajanen, MT Jaklitsch… - Journal of surgical …, 2023 - Wiley Online Library
The surgical management of pleural mesothelioma (PM) can be divided into diagnostic,
staging, palliation, and cytoreductive surgery. In the cytoreductive surgical setting, the …

The rocky road from preclinical findings to successful targeted therapy in pleural mesothelioma

J Paajanen, R Bueno, A De Rienzo - International Journal of Molecular …, 2022 - mdpi.com
Pleural mesothelioma (PM) is a rare and aggressive disease that arises from the mesothelial
cells lining the pleural cavity. Approximately 80% of PM patients have a history of asbestos …

KRAS mutations are associated with shortened survival in patients with epithelioid malignant pleural mesothelioma

M Vannucchi, V Pennati, C Mencaroni, C Defraia… - Cancers, 2023 - mdpi.com
Simple Summary Malignant pleural mesothelioma (MPM) is an aggressive tumor with
implacable prognosis. It commonly harbors loss-of-function mutations in BAP1, NF2 …

Recurrence Patterns and Management after Pleurectomy Decortication for Pleural Mesothelioma

J Paajanen, WG Richards, Y **e, E Mazzola… - Annals of …, 2025 - journals.lww.com
Objective: We hypothesize that recurrence following pleurectomy decortication (PD) is
primarily local. We explored factors associated with tumor recurrence patterns, disease-free …

Unprecedented long‐term survival in a patient with malignant pleural mesothelioma treated with subsequent systemic chemo‐and immunotherapeutic regimens

L Cerbone, S Delfanti, AM De Angelis… - Thoracic …, 2023 - Wiley Online Library
Pleural mesothelioma is a rare disease with a dismal prognosis and few therapeutic options.
Until recently the median overall survival for a pleural mesothelioma patient was up to 2 …

High tumor cell platelet‐derived growth factor receptor beta expression is associated with shorter survival in malignant pleural epithelioid mesothelioma

H Ollila, J Paajanen, H Wolff, I Ilonen… - The Journal of …, 2021 - Wiley Online Library
Malignant pleural mesothelioma (MPM) has a rich stromal component containing
mesenchymal fibroblasts. However, the properties and interplay of MPM tumor cells and …

化学療法による長期奏効後, 10 年で再発を認めた上皮型悪性胸膜中皮腫の 1 例

橋田恵佑, 大塚浩二郎, 田中悠也, 稲尾崇, 門田和也… - 肺癌, 2023 - jstage.jst.go.jp
抄録 背景. アスベスト曝露関連疾患である悪性胸膜中皮腫は免疫チェックポイント阻害薬の登場
など治療選択肢が**年増えてはいるが, 依然として予後不良の疾患である. 一方で長期生存例が …

Mesothelioma in 2024: What's New?

L Giannakou, H Yang, M Carbone - Asbestos, 2025 - taylorfrancis.com
Mesothelioma is a malignancy of the pleura, less frequently the peritoneum, rarely the
pericardium or tunica vaginalis. Most mesotheliomas are very aggressive and resistant to …

Targeted therapies for Malignant Mesothelioma

V Angiolini - 2025 - tesidottorato.depositolegale.it
Malignant mesothelioma (MM) is an aggressive neoplasia arising from mesothelial cells that
line serous cavities, such as pleura, peritoneum, pericardium, and vaginal tunic. It is defined …

10 MesotheliomaWhat'sNew? in 2024

L Giannakou, H Yang, M Carbone - Asbestos: Risk Assessment …, 2024 - books.google.com
Mesothelioma originates from the mesothelial cells that form the pleura and the peritoneum.
Mesothelial cells are the last remnant of the mesoderm that covers the celomic cavity, which …