Programmed cell death (PCD) pathways, including apoptosis and regulated necrosis, are
required for normal cell turnover and tissue homeostasis. Mis-regulation of PCD is …

Saccharomyces cerevisiae has directly or indirectly contributed to the identification of
arguably more mammalian genes that affect aging than any other model organism. Aging in …

Polyamines are polycations that interact with negatively charged molecules such as DNA,
RNA and proteins. They play multiple roles in cell growth, survival and proliferation …

Lysosomes are the main catabolic organelles of a cell and play a pivotal role in a plethora of
cellular processes, including responses to nutrient availability and composition, stress …

Yeasts, such as Saccharomyces cerevisiae, have long served as useful models for the study
of oxidative stress, an event associated with cell death and severe human pathologies. This …

Elucidating the biology of yeast in its full complexity has major implications for science,
medicine and industry. One of the most critical processes determining yeast life and …

The naturally occurring polyamine spermidine (Spd) has recently been shown to promote
longevity across species in an autophagy-dependent manner. Here, we demonstrate that …

Ageing constitutes the most important risk factor for all major chronic ailments, including
malignant, cardiovascular and neurodegenerative diseases. However, behavioural and …

Background: Spermidine, a naturally occurring polyamine, has recently emerged as
exhibiting anti-aging properties. Its supplementation increases lifespan and resistance to …

Polyamines (PAs) have been considered as important molecules for survival. However,
evidence reinforces that PAs are also implicated, directly or indirectly, in pathways …