Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment

RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Nonsocial and social cognition in schizophrenia: current evidence and future directions

MF Green, WP Horan, J Lee - World psychiatry, 2019 - Wiley Online Library
Cognitive impairment in schizophrenia involves a broad array of nonsocial and social
cognitive domains. It is a core feature of the illness, and one with substantial implications for …

Mental health in elite athletes: International Olympic Committee consensus statement (2019)

CL Reardon, B Hainline, CM Aron, D Baron… - British journal of sports …, 2019 - bjsm.bmj.com
Mental health symptoms and disorders are common among elite athletes, may have sport
related manifestations within this population and impair performance. Mental health cannot …

Mechanisms underlying dorsolateral prefrontal cortex contributions to cognitive dysfunction in schizophrenia

J Smucny, SJ Dienel, DA Lewis… - …, 2022 - nature.com
Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …

The schizophrenia syndrome, circa 2024: What we know and how that informs its nature

R Tandon, H Nasrallah, S Akbarian… - Schizophrenia …, 2024 - Elsevier
With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …

The clinical characterization of the patient with primary psychosis aimed at personalization of management

M Maj, J van Os, M De Hert, W Gaebel… - World …, 2021 - Wiley Online Library
The current management of patients with primary psychosis worldwide is often remarkably
stereotyped. In almost all cases an antipsychotic medication is prescribed, with second …

European Psychiatric Association guidance on assessment of cognitive impairment in schizophrenia

A Vita, W Gaebel, A Mucci, G Sachs, A Erfurth… - European …, 2022 - cambridge.org
Background Impairment in a wide range of cognitive abilities has been consistently reported
in individuals with schizophrenia. Both neurocognitive and social cognitive deficits are …

PV interneurons: critical regulators of E/I balance for prefrontal cortex-dependent behavior and psychiatric disorders

BR Ferguson, WJ Gao - Frontiers in neural circuits, 2018 - frontiersin.org
Elucidating the prefrontal cortical microcircuit has been challenging, given its role in multiple
complex behaviors, including working memory, cognitive flexibility, attention, social …

Cognitive function and variability in antipsychotic drug–naive patients with first-episode psychosis: a systematic review and meta-analysis

M Lee, M Cernvall, J Borg, P Plavén-Sigray… - JAMA …, 2024 - jamanetwork.com
Importance Cognitive impairment contributes significantly to clinical outcome and level of
function in individuals with psychotic disorders. These impairments are present already at …

Social cognition in schizophrenia

MF Green, WP Horan, J Lee - Nature Reviews Neuroscience, 2015 - nature.com
Individuals with schizophrenia exhibit impaired social cognition, which manifests as
difficulties in identifying emotions, feeing connected to others, inferring people's thoughts …