Benefiting from the impressive increase in fundamental knowledge, the last 20 years have
shown a continuous burst of new ideas and consequently a plethora of new catalytic …

Nitroxides, also known as nitroxyl radicals, are long-lived or stable radicals with the general
structure R1R2N–O•. The spin distribution over the nitroxide N and O atoms contributes to …

Conspectus In nature, enzymes are a powerful medium for the construction of
enantiomerically pure chemicals, which always inspires synthetic chemists to explore new …

In nature, a number of enzymes use thiamine diphosphate as a coenzyme to catalyze the
pyruvate decarboxylation. The resultant enamine, a so-called “Breslow intermediate,” is …

Despite the great potential of radical chemistry in organic synthesis, N‐heterocyclic carbene
(NHC)‐catalyzed reactions involving radical intermediates are not well explored. This …

Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes | Chemical Reviews ACS
ACS Publications C&EN CAS Find my institution Log In Chemical Reviews ACS Publications …

Conspectus This Account is aimed at highlighting the recent developments in the N-
heterocyclic carbene (NHC)-catalyzed generation of α, β-unsaturated acylazolium …

N‐Heterocyclic carbene (NHC) organocatalysis has been developed as an important
approach in modern organic synthesis. Versatile activation modes within NHC …

First reported less than a decade ago, the α, β-unsaturated acyl azolium has emerged as a
central reactive intermediate for reaction discovery using N-heterocyclic carbene catalysis …

α, β-Unsaturated carbonyl compounds are key building blocks in organic chemistry. Their
catalytic synthesis has received significant attention during the past decades. Among the …