Ensuring consistent high yields and product quality are key challenges in biomanufacturing.
Even minor deviations in critical process parameters (CPPs) such as media and feed …

In order to meet the rising demand for biologics and become competitive on the develo**
biosimilar market, there is a need for process intensification of biomanufacturing processes …

Mass spectrometry-based omics technologies are increasingly used in perturbation studies
to map drug effects to biological pathways by identifying significant molecular events …

Mammalian cell lines are frequently used as the preferred host cells for producing
recombinant therapeutic proteins (RTPs) having post-translational modified modification …

The multicolumn counter-current solvent gradient purification (MCSGP) method has proven
effective in addressing the issue of elution profile overlap for difficult-to-separate proteins …

Culture conditions have a profound impact on therapeutic protein production and
glycosylation, a critical therapeutic-quality attribute, especially for monoclonal antibodies …

Chinese hamster ovary (CHO) cells are the most commonly used host cells for the
production of recombinant monoclonal antibodies (mAbs) due to their several advantages …

Chinese hamster ovary (CHO) cells are the preferred mammalian host for the large-scale
production of recombinant proteins in the biopharmaceutical industry. Research endeavors …

We present a detailed mass spectrometric analysis of three 2+ 1 T-cell bispecific monoclonal
antibodies (TCB mAbs), where an unexpected+ 15.9950 Da mass shift in tryptic peptides …

Bioprocess development benefits from kinetic models in many aspects, including scale-up,
optimization, and process understanding. However, current models are unable to simulate …