Current and future trends on diagnosis and prognosis of glioblastoma: from molecular biology to proteomics
Glioblastoma multiforme is the most aggressive malignant tumor of the central nervous
system. Due to the absence of effective pharmacological and surgical treatments, the …
system. Due to the absence of effective pharmacological and surgical treatments, the …
[HTML][HTML] Extracellular matrix in glioblastoma: opportunities for emerging therapeutic approaches
E Mohiuddin, H Wakimoto - American journal of cancer research, 2021 - ncbi.nlm.nih.gov
Extracellular matrix is a complex network of macromolecules that constitute a
microenvironment of normal tissues and malignancies such as the primary brain tumor …
microenvironment of normal tissues and malignancies such as the primary brain tumor …
Small interfering RNA (siRNA) to target genes and molecular pathways in glioblastoma therapy: Current status with an emphasis on delivery systems
Glioblastoma multiforme (GBM) is one of the worst brain tumors arising from glial cells,
causing many deaths annually. Surgery, chemotherapy, radiotherapy and immunotherapy …
causing many deaths annually. Surgery, chemotherapy, radiotherapy and immunotherapy …
[HTML][HTML] Harnessing mitochondrial metabolism and drug resistance in non-small cell lung cancer and beyond by blocking heat-shock proteins
Lung cancer is the leading cause of cancer-related deaths worldwide, with non-small cell
lung cancer (NSCLC) being the predominant histological subtype. Despite the emergence of …
lung cancer (NSCLC) being the predominant histological subtype. Despite the emergence of …
Progress in natural compounds/siRNA co-delivery employing nanovehicles for cancer therapy
Chemotherapy using natural compounds, such as resveratrol, curcumin, paclitaxel,
docetaxel, etoposide, doxorubicin, and camptothecin, is of importance in cancer therapy …
docetaxel, etoposide, doxorubicin, and camptothecin, is of importance in cancer therapy …
Molecular chaperones in cancer stem cells: determinants of stemness and potential targets for antitumor therapy
A Kabakov, A Yakimova, O Matchuk - Cells, 2020 - mdpi.com
Cancer stem cells (CSCs) are a great challenge in the fight against cancer because these
self-renewing tumorigenic cell fractions are thought to be responsible for metastasis …
self-renewing tumorigenic cell fractions are thought to be responsible for metastasis …
Discovery of novel HSP27 inhibitors as prospective anti-cancer agents utilizing computer-assisted therapeutic discovery approaches
Heat shock protein 27 (HSP27) is a protein that works as a chaperone and an antioxidant
and is activated by heat shock, environmental stress, and pathophysiological stress …
and is activated by heat shock, environmental stress, and pathophysiological stress …
Mangiferin prevents hepatocyte epithelial‐mesenchymal transition in liver fibrosis via targeting HSP27‐mediated JAK2/STAT3 and TGF‐β1/Smad pathway
X Zhang, X Zhang, X Ge, M Liu - Phytotherapy Research, 2022 - Wiley Online Library
Hepatocytes has been confirmed to undergo EMT and can be converted into myofibroblasts
during hepatic fibrogenesis. However, the mechanism of hepatocyte EMT regulation in …
during hepatic fibrogenesis. However, the mechanism of hepatocyte EMT regulation in …
Deciphering the lexicon of protein targets: a review on multifaceted drug discovery in the era of artificial intelligence
Understanding protein sequence and structure is essential for understanding protein–
protein interactions (PPIs), which are essential for many biological processes and diseases …
protein interactions (PPIs), which are essential for many biological processes and diseases …
Tumor dormancy and reactivation: the role of heat shock proteins
HA Amissah, SE Combs, M Shevtsov - Cells, 2024 - mdpi.com
Tumors are a heterogeneous group of cell masses originating in various organs or tissues.
The cellular composition of the tumor cell mass interacts in an intricate manner, influenced …
The cellular composition of the tumor cell mass interacts in an intricate manner, influenced …