Cubic phase gels as drug delivery systems

JC Shah, Y Sadhale, DM Chilukuri - Advanced drug delivery reviews, 2001 - Elsevier
Lipids have been used extensively for drug delivery in various forms such as liposomes, and
solid-matrices. The focus of this review is evaluation of liquid crystalline cubic phases …

Factors affecting the structure of lyotropic liquid crystals and the correlation between structure and drug diffusion

Y Huang, S Gui - RSC advances, 2018 - pubs.rsc.org
Lyotropic liquid crystals (LLCs) formed by the self-assembly of amphiphilic molecules in a
solvent (usually water) have attracted increasingly greater attention in the last few decades …

[BOOK][B] The structure of biological membranes

PL Yeagle - 2004 - taylorfrancis.com
Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …

Cubic and hexagonal liquid crystals as drug delivery systems

Y Chen, P Ma, S Gui - BioMed research international, 2014 - Wiley Online Library
Lipids have been widely used as main constituents in various drug delivery systems, such
as liposomes, solid lipid nanoparticles, nanostructured lipid carriers, and lipid‐based …

The modified stalk mechanism of lamellar/inverted phase transitions and its implications for membrane fusion

DP Siegel - Biophysical journal, 1999 - cell.com
A model of the energetics of lipid assemblies (Siegel. 1993. Biophys. J. 65: 2124–2140) is
used to predict the relative free energy of intermediates in the transitions between lamellar …

Controlling molecular transport and sustained drug release in lipid-based liquid crystalline mesophases

A Zabara, R Mezzenga - Journal of Controlled Release, 2014 - Elsevier
Lipid-based lyotropic liquid crystals, also referred to as reversed liquid crystalline
mesophases, such as bicontinuous cubic, hexagonal or micellar cubic phases, have …

Mechanism of the lamellar/inverse hexagonal phase transition examined by high resolution x-ray diffraction

M Rappolt, A Hickel, F Bringezu, K Lohner - Biophysical journal, 2003 - cell.com
For the first time the electron density of the lamellar liquid crystalline as well as of the
inverted hexagonal phase could be retrieved at the transition temperature. A reliable …

Inverse lyotropic phases of lipids and membrane curvature

GC Shearman, O Ces, RH Templer… - Journal of Physics …, 2006 - iopscience.iop.org
In recent years it has become evident that many biological functions and processes are
associated with the adoption by cellular membranes of complex geometries, at least locally …

The Gaussian curvature elastic modulus of N-monomethylated dioleoylphosphatidylethanolamine: relevance to membrane fusion and lipid phase behavior

DP Siegel, MM Kozlov - Biophysical journal, 2004 - cell.com
The energy of intermediates in fusion of phospholipid bilayers is sensitive to κ¯ m, the
saddle splay (Gaussian curvature) elastic modulus of the lipid monolayers. The value κ¯ m …

Long acting injectable formulations: the state of the arts and challenges of poly (lactic-co-glycolic acid) microsphere, hydrogel, organogel and liquid crystal

WY Lee, M Asadujjaman, JP Jee - Journal of Pharmaceutical Investigation, 2019 - Springer
Background Long-acting injectable formulations (LAIFs) have received substantial attention
recently due to their advantages over conventional formulations, including easy …