Radiolabeled nanomaterial for cancer diagnostics and therapeutics: principles and concepts

M Goel, Y Mackeyev, S Krishnan - Cancer Nanotechnology, 2023 - Springer
In the last three decades, radiopharmaceuticals have proven their effectiveness for cancer
diagnosis and therapy. In parallel, the advances in nanotechnology have fueled a plethora …

Prospects of nanoparticle-based radioenhancement for radiotherapy

LRH Gerken, ME Gerdes, M Pruschy… - Materials horizons, 2023 - pubs.rsc.org
Radiotherapy is a key pillar of solid cancer treatment. Despite high level of conformal dose
deposition, radiotherapy is limited due to co-irradiation of organs-at risk and subsequent …

Self-therapeutic nanomaterials: Applications in biology and medicine

J Seaberg, JR Clegg, R Bhattacharya, P Mukherjee - Materials Today, 2023 - Elsevier
Over past decades, nanotechnology has contributed to the biomedical field in areas
including detection, diagnosis, and drug delivery via opto-electronic properties or …

Tailoring radiotherapies and nanotechnology for targeted treatment of solid tumors

MI Khan, F Batool, R Ali, W Wang, S Li, G Wang… - Coordination Chemistry …, 2022 - Elsevier
Existing anticancer therapeutic modalities in clinical settings lack efficacy and fail to
completely cure cancers. Clearly understandable and mechanistic approaches are …

In vitro and in vivo evaluation of 211At-labeled fibroblast activation protein inhibitor for glioma treatment

H Ma, F Li, G Shen, L Pan, W Liu, R Liang, T Lan… - Bioorganic & Medicinal …, 2022 - Elsevier
Glioma is the most common primary intracranial tumor without effective treatment. Positron
emission tomography tracers labeled with 68 Ga targeting fibroblast activation protein (FAP) …

Recent progress of astatine-211 in endoradiotherapy: Great advances from fundamental properties to targeted radiopharmaceuticals

F Li, Y Yang, J Liao, N Liu - Chinese Chemical Letters, 2022 - Elsevier
Abstract Astatine-211 (211 At, t 1/2= 7.21 h) emitting two α particles with energies of 5.87
and 7.45 MeV, can lead to a high linear energy transfer (LET= 98.84 keV/µm) and short …

Development of a 213bi-labeled pyridyl benzofuran for targeted α-therapy of amyloid-β aggregates

AA Bender, EK Kirkeby, DJ Cross… - Journal of Nuclear …, 2024 - jnm.snmjournals.org
Alzheimer disease is a neurodegenerative disorder with limited treatment options. It is
characterized by the presence of several biomarkers, including amyloid-β aggregates, which …

The current status and future directions on nanoparticles for tumor molecular imaging

C Yin, P Hu, L Qin, Z Wang, H Zhao - International Journal of …, 2024 - Taylor & Francis
Molecular imaging is an advanced technology that utilizes specific probes or markers in
conjunction with cutting-edge imaging techniques to observe and analyze the localization …

Theranostic nanoparticles for detection and treatment of pancreatic cancer

H Agarwal, RC Bynum, N Saleh… - Wiley …, 2024 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is one of the most recalcitrant cancers due to its
late diagnosis, poor therapeutic response, and highly heterogeneous microenvironment …

Radioimmunoconjugates in the age of modern immuno-oncology

D Nasr, PA Kumar, MB Zerdan, G Ghelani, D Dutta… - Life Sciences, 2022 - Elsevier
Immunotherapy was first investigated as a therapeutic option for treating cancer more than a
century ago. During this period, it has gone through numerous disappointments when the …