Proteogenomics is an area of research at the interface of proteomics and genomics. In this
approach, customized protein sequence databases generated using genomic and …

Many publicly available data repositories and resources have been developed to support
protein-related information management, data-driven hypothesis generation, and biological …

Background: Fusion transcripts are formed by either fusion genes (DNA level) or trans-
splicing events (RNA level). They have been recognized as a promising tool for diagnosing …

Although gene fusions have been recognized as important drivers of cancer for decades,
our understanding of the prevalence and function of gene fusions has been revolutionized …

The complexities of tumor genomes are rapidly being uncovered, but how they are regulated
into functional proteomes remains poorly understood. Standard proteomics workflows use …

Background De novo transcriptome assembly of short reads is now a common step in
expression analysis of organisms lacking a reference genome sequence. Several software …

Pre-RNA splicing is an essential step in generating mature mRNA. RNA trans-splicing
combines two separate pre-mRNA molecules to form a chimeric non-co-linear RNA, which …

Mechanistically, chimeric genes result from DNA rearrangements and include parts of
preexisting normal genes combined at the genomic junction site. Some rearranged genes …

Trans-splicing is a post-transcriptional event that joins exons from separate pre-mRNAs.
Detection of trans-splicing is usually severely hampered by experimental artifacts and …

Fusion gene is an important class of therapeutic targets and prognostic markers in cancer.
ChimerDB is a comprehensive database of fusion genes encompassing analysis of deep …