Develo** greener synthesis processes is an inescapable necessity to transform the
industrial landscape, mainly in the pharmaceutical sector, into a long-term, sustainable …

The biopharmaceutical market has experienced a tremendous growth in the last years.
However, this growth should be balanced considering the difficulty in bioproduct …

RNA oligonucleotides have emerged as a powerful therapeutic modality to treat disease, yet
current manufacturing methods may not be able to deliver on anticipated future demand …

RNA therapeutics are a promising strategy to treat genetic diseases caused by the
overexpression or aberrant splicing of a specific protein. The field has seen major strides in …

In recent decades, there has been a trend toward using larger biological molecules as new
active pharmaceutical ingredients (APIs) instead of the classical small organic API …

Single-column (batch) preparative chromatography is the technique of choice for purification
of biotherapeutics but it is often characterized by an intrinsic limitation in terms of yield-purity …

The great versatility and controllable properties that characterize polymeric materials
allowed their spreading to many different areas. In the last years, this outstanding …

Oligonucleotides (ONs) are acquiring clinical relevance and their demand is expected to
grow. However, the ON production capacity is currently limited by high manufacturing costs …

Support vector regression models are created and used to predict the retention times of
oligonucleotides separated using gradient ion-pair chromatography with high accuracy. The …

Here it was investigated how oligonucleotide retention and selectivity factors are affected by
electrostatic and non-electrostatic interactions in ion pair chromatography. A framework was …