Abstract Purpose of Review In this review, we highlight the most important cellular and
molecular mechanisms that contribute to cardiac inflammation and fibrosis. We also discuss …

The cardiac extracellular matrix (ECM) is a complex architectural network consisting of
structural and nonstructural proteins, creating strength and plasticity. The nonstructural …

Heart failure (HF) is a global medical problem that characterizes poor prognosis and high
economic burden for the health system and family of the HF patients. Although modern …

Lumbar discectomy is a very effective therapy for neurological decompression in patients
suffering from sciatica due to hernia nuclei pulposus. However, high recurrence rates and …

Extracellular matrix remodeling is extensive in several heart diseases and hampers cardiac
filling, often leading to heart failure. Proteoglycans have over the last two decades emerged …

Heart failure is accompanied by adverse cardiac remodeling involving extracellular matrix
(ECM). Cardiac ECM acts as a major reservoir for many proteins including growth factors …

Ventricular remodeling occurs progressively in untreated patients after large myocardial
infarction and in those with cardiomyopathy. The pathologic changes of increased left …

Fatal Lyme carditis caused by the spirochete Borrelia burgdorferi rarely is identified. Here,
we describe the pathologic, immunohistochemical, and molecular findings of five case …

Despite significant advances in treating heart disease, heart failure remains a major cause
of morbidity and mortality. Regardless of the initiating cause (s), heart failure is associated …

The extracellular matrix (ECM) provides structural support and a microenvironmentfor
soluble extracellular molecules. ECM is comprised of numerous proteins which can be …