Fatty acids are metabolized and synthesized as energy substrates during biological
responses. Long-and medium-chain fatty acids derived mainly from dietary triglycerides, and …

G protein-coupled receptors (GPCRs) are historically the most successful family of drug
targets. In recent times it has become clear that the pharmacology of these receptors is far …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

FFAR1 is a G-protein-coupled receptor (GPCR) that responds to circulating free fatty acids to
enhance glucose-stimulated insulin secretion and release of incretin hormones. Due to the …

Several G protein-coupled receptors (GPCRs) that are activated by intermediates of energy
metabolism—such as fatty acids, saccharides, lactate and ketone bodies—have recently …

Identification of G protein-coupled receptors that are activated by free fatty acids has led to
considerable interest in their pharmacology and function because of the wide range of …

Label-free biosensor technology based on dynamic mass redistribution (DMR) of cellular
constituents promises to translate GPCR signaling into complex optical'fingerprints' in real …

Glucose homeostasis requires the highly coordinated regulation of insulin secretion by
pancreatic β cells. This is primarily mediated by glucose itself, but other nutrients, including …

G protein-coupled receptors (GPCRs) make up the largest receptor superfamily, accounting
for 4% of protein-coding genes. Despite the prevalence of such transmembrane receptors, a …

Endocannabinoids (eCBs) regulate a broad range of physiological functions in the postnatal
brain and are implicated in the neuropathogenesis of psychiatric and metabolic diseases …