Inflammatory and metabolic signaling interfaces of the hypertrophic and senescent chondrocyte phenotypes associated with osteoarthritis
Osteoarthritis (OA) is a complex disease of whole joints with progressive cartilage matrix
degradation and chondrocyte transformation. The inflammatory features of OA are reflected …
degradation and chondrocyte transformation. The inflammatory features of OA are reflected …
Role of physical exercise and nutraceuticals in modulating molecular pathways of osteoarthritis
A de Sire, N Marotta, C Marinaro, C Curci… - International Journal of …, 2021 - mdpi.com
Osteoarthritis (OA) is a painful and disabling disease that affects millions of patients. Its
etiology is largely unknown, but it is most likely multifactorial. OA pathogenesis involves the …
etiology is largely unknown, but it is most likely multifactorial. OA pathogenesis involves the …
Exploration of binding mechanism of apigenin to pepsin: Spectroscopic analysis, molecular docking, enzyme activity and antioxidant assays
J Guo, C Gan, B Cheng, B Cui, F Yi - Spectrochimica Acta Part A: Molecular …, 2023 - Elsevier
Pepsin plays an important role in nutrient metabolism. Apigenin (AP) is a beneficial
polyphenol to human health. To enhance the bioavailability of AP and elucidate the …
polyphenol to human health. To enhance the bioavailability of AP and elucidate the …
Mechanism of HIFs in osteoarthritis
XA Zhang, H Kong - Frontiers in Immunology, 2023 - frontiersin.org
Osteoarthritis (OA) is a common disabling disease which has a high incidence rate in the
elderly. Studies have found that many factors are involved in the pathogenesis of OA …
elderly. Studies have found that many factors are involved in the pathogenesis of OA …
[HTML][HTML] The metabolic landscape in osteoarthritis
Articular cartilage function depends on the temporal and zonal distribution of coordinated
metabolic regulation in chondrocytes. Emerging evidence shows the importance of cellular …
metabolic regulation in chondrocytes. Emerging evidence shows the importance of cellular …
[HTML][HTML] Prussian blue nanozymes coated with Pluronic attenuate inflammatory osteoarthritis by blocking c-Jun N-terminal kinase phosphorylation
C Cho, H Oh, JS Lee, LJ Kang, EJ Oh, Y Hwang… - Biomaterials, 2023 - Elsevier
Osteoarthritis (OA) is a degenerative joint disorder associated with inflammation, functional
disability, and high socioeconomic costs. The development of effective therapies against …
disability, and high socioeconomic costs. The development of effective therapies against …
Mechanisms of immune response and cell death in ischemic stroke and their regulation by natural compounds
Z Gong, J Guo, B Liu, Y Guo, C Cheng, Y Jiang… - Frontiers in …, 2024 - frontiersin.org
Ischemic stroke (IS), which is the third foremost cause of disability and death worldwide, has
inflammation and cell death as its main pathological features. IS can lead to neuronal cell …
inflammation and cell death as its main pathological features. IS can lead to neuronal cell …
Antiosteoarthritic effect of morroniside in chondrocyte inflammation and destabilization of medial meniscus-induced mouse model
E Park, CG Lee, SJ Han, SH Yun, S Hwang… - International Journal of …, 2021 - mdpi.com
Osteoarthritis (OA) is a common degenerative disease that results in joint inflammation as
well as pain and stiffness. A previous study has reported that Cornus officinalis (CO) extract …
well as pain and stiffness. A previous study has reported that Cornus officinalis (CO) extract …
Natural anti‐inflammatory products for osteoarthritis: From molecular mechanism to drug delivery systems and clinical trials
J Su, M Yu, H Wang, Y Wei - Phytotherapy Research, 2023 - Wiley Online Library
Osteoarthritis (OA) is a degenerative joint disease that affects millions globally. The present
nonsteroidal anti‐inflammatory drug treatments have different side effects, leading …
nonsteroidal anti‐inflammatory drug treatments have different side effects, leading …
Characterization of the glucuronidating pathway of pectolinarigenin, the major active constituent of the Chinese medicine Daji, in humans and its influence on …
P Liu, Q Li, G Zhu, T Zhang, D Tu, F Zhang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance The Chinese medicine Daji (the aerial part of
Cirsium japonicum DC.) and its charred product (Cirsii Japonici Herba Carbonisata) have …
Cirsium japonicum DC.) and its charred product (Cirsii Japonici Herba Carbonisata) have …