Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad of vital
functions across diverse cellular processes. Dysfunctions within mitochondria serve as …

Biological cell membranes are a natural barrier for living cells. In the last few decades, the
cell membrane has been the main hurdle in the efficient delivery of bioactive and therapeutic …

Cell-penetrating peptides (CPPs), developed for more than 30 years, are still being
extensively studied due to their excellent delivery performance. Compared with other …

Myocardial ischemia-reperfusion injury (MI/RI) seriously restricts the therapeutic effect of
reperfusion. It is demonstrated that ferroptosis and apoptosis of cardiomyocytes are widely …

Matrix metalloproteinases (MMPs) are a class of endopeptidases that are dependent on zinc
and facilitate the degradation of extracellular matrix (ECM) proteins, thereby playing pivotal …

Natural enzymes are efficient and versatile biocatalysts but suffer in their environmental
tolerance and catalytic stability. As artificial enzymes, nanozymes can improve the catalytic …

Well-developed mitochondria-targeted nanocarriers for function regulation are highly
desirable. Numerous studies have been conducted on the treatment of mitochondria-related …

For patients suffering from traumatic brain injury (TBI), the closure of dural defects after
decompressive craniectomy is the prerequisite to restoring normal physiological functions. It …

Cell-penetrating peptides (CPPs) are promising vehicles for intracellular delivery of different
cargoes. Although various CPPs are designed for targeted delivery of nanomedicines and …

Nanomedicine has emerged as a revolutionary strategy of drug delivery. However,
fundamentals of the nano–neuro interaction are elusive. In particular, whether nanocarriers …