Emergence of Marburg virus: a global perspective on fatal outbreaks and clinical challenges

S Srivastava, D Sharma, S Kumar, A Sharma… - Frontiers in …, 2023‏ - frontiersin.org
The Marburg virus (MV), identified in 1967, has caused deadly outbreaks worldwide, the
mortality rate of Marburg virus disease (MVD) varies depending on the outbreak and virus …

Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus

I Messaoudi, GK Amarasinghe, CF Basler - Nature Reviews …, 2015‏ - nature.com
Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens
that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in …

Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use

JF Atkins, G Loughran, PR Bhatt, AE Firth… - Nucleic acids …, 2016‏ - academic.oup.com
Genetic decoding is not 'frozen'as was earlier thought, but dynamic. One facet of this is
frameshifting that often results in synthesis of a C-terminal region encoded by a new frame …

Transcriptional slippage in the positive‐sense RNA virus family Potyviridae

A Olspert, BYW Chung, JF Atkins, JP Carr, AE Firth - EMBO reports, 2015‏ - embopress.org
The family Potyviridae encompasses~ 30% of plant viruses and is responsible for significant
economic losses worldwide. Recently, a small overlap** coding sequence, termed pipo …

Mechanisms and concepts in RNA virus population dynamics and evolution

PT Dolan, ZJ Whitfield, R Andino - Annual Review of Virology, 2018‏ - annualreviews.org
RNA viruses are unique in their evolutionary capacity, exhibiting high mutation rates and
frequent recombination. They rapidly adapt to environmental changes, such as shifts in …

RNA polymerase slippage as a mechanism for the production of frameshift gene products in plant viruses of the Potyviridae family

B Rodamilans, A Valli, A Mingot, D San León… - Journal of …, 2015‏ - journals.asm.org
Modifications of RNA sequences by nucleotide insertions, de-letions, or substitutions can
result in the expression of multiple proteins in overlap** open reading frames (ORFs). In …

[HTML][HTML] An intrinsically disordered peptide from Ebola virus VP35 controls viral RNA synthesis by modulating nucleoprotein-RNA interactions

DW Leung, D Borek, P Luthra, JM Binning… - Cell reports, 2015‏ - cell.com
During viral RNA synthesis, Ebola virus (EBOV) nucleoprotein (NP) alternates between an
RNA-template-bound form and a template-free form to provide the viral polymerase access …

[HTML][HTML] New perspectives on the biogenesis of viral inclusion bodies in negative-sense RNA virus infections

O Dolnik, GK Gerresheim, N Biedenkopf - Cells, 2021‏ - mdpi.com
Infections by negative strand RNA viruses (NSVs) induce the formation of viral inclusion
bodies (IBs) in the host cell that segregate viral as well as cellular proteins to enable efficient …

ADAR editing in viruses: an evolutionary force to reckon with

H Piontkivska, B Wales-McGrath… - Genome biology and …, 2021‏ - academic.oup.com
Abstract Adenosine Deaminases that Act on RNA (ADARs) are RNA editing enzymes that
play a dynamic and nuanced role in regulating transcriptome and proteome diversity. This …

Unconventional viral gene expression mechanisms as therapeutic targets

JSY Ho, Z Zhu, I Marazzi - Nature, 2021‏ - nature.com
Unlike the human genome that comprises mostly noncoding and regulatory sequences,
viruses have evolved under the constraints of maintaining a small genome size while …