The aging process worsens the human body functions at multiple levels, thus causing its
gradual decrease to resist stress, damage, and disease. Besides changes in gene …

Deregulation of the cell cycle machinery is a hallmark of cancer. While CDK4/6 inhibitors are
FDA approved (palbociclib) for treating advanced estrogen receptor-positive breast cancer …

Obesity-induced diabetes is characterized by hyperglycemia, insulin resistance, and
progressive beta cell failure. In islets of mice with obesity-induced diabetes, we observe …

Due to their crucial role in cell metabolism and homeostasis, alterations in mitochondrial
biology and function have been related to the progression of diverse diseases including …

Bioenergetic failure and oxidative stress are common pathological hallmarks of amyotrophic
lateral sclerosis (ALS), but whether these could be targeted effectively for novel therapeutic …

Pancreatic inflammation is a risk factor for the development of pancreatic cancer. Increased
presence of inflammatory macrophages can be found in response to a KRAS mutation in …

Induction of reactive oxygen species (ROS) production in cancer cells plays a critical role for
cancer treatment. However, therapeutic efficiency remains challenging due to insufficient …

Abstract NADPH oxidases 2 (NOX2) is the main source of ROS in macrophages, which
plays a critical role in the formation of atherosclerosis. However, effects of NOX2 inhibition …

Notch signaling plays important roles in the regulation of immune cell functioning during the
inflammatory response. Activation of the innate immune signaling receptor NLRP3 promotes …

The Warburg effect is important for cancer cell proliferation. This phenomenon can be
flexible by interaction between glycolysis and mitochondrial oxidation for energy production …