Abstract Cyclic nucleotides 3′, 5′-cAMP and 3′, 5′-cGMP are now established
signaling components of the plant cell while their 2′, 3′ positional isomers are …

Over the past decade, our understanding of the mechanisms by which pseudokinases,
which comprise∼ 10% of the human and mouse kinomes, mediate signal transduction has …

Abstract The SARS-CoV-2 Omicron variant containing 15 mutations, including the unique
Q493R, in the spike protein receptor binding domain (S1-RBD) is highly infectious. While …

Background Familial diarrhea disorders are, in most cases, severe and caused by recessive
mutations. We describe the cause of a novel dominant disease in 32 members of a …

Apicomplexan parasites rely on cyclic nucleotide-dependent kinases for host cell infection,
yet the mechanisms that control their activation remain unknown. Here we show that an …

Phytosulfokines (PSKs) are sulfated pentapeptides that stimulate plant growth and
differentiation mediated by the PSK receptor (PSKR1), which is a leucine-rich repeat …

Blastocladiomycota fungi form motile zoospores that are guided by sensory photoreceptors
to areas of optimal light conditions. We showed that the microbial rhodopsin of …

The GUCY2D gene encodes for the photoreceptor guanylate cyclase GC-E that synthesizes
the intracellular messenger of photoreceptor excitation cGMP and is regulated by …

Moonlighting functional centers within proteins can provide them with hitherto unrecognized
functions. Here, we review how hidden moonlighting functional centers, which we define as …

Receptor guanylyl cyclase C (GC-C) is the target for the gastrointestinal hormones, guanylin,
and uroguanylin as well as the bacterial heat-stable enterotoxins. The major site of …