The past 20 years have seen enormous progress in the understanding of the mechanisms
used by the enteric bacterium Escherichia coli to promote protein folding, support protein …

▪ Abstract Proteolysis in Escherichia coli serves to rid the cell of abnormal and misfolded
proteins and to limit the time and amounts of availability of critical regulatory proteins. Most …

Early-onset torsion dystonia is a movement disorder, characterized by twisting muscle
contractures, that begins in childhood. Symptoms are believed to result from altered …

Interruption of translation in Escherichia coli can lead to the addition of an 11-residue
carboxy-terminal peptide tail to the nascent chain. This modification is mediated by SsrA …

SUMMARY α-Crystallins were originally recognized as proteins contributing to the
transparency of the mammalian eye lens. Subsequently, they have been found in many, but …

Proteases and chaperones together serve to maintain quahty control of cellular proteins.
Both types of en zymes have as their substrates the variety of misfolded and partially folded …

▪ Abstract Proteasomes are large multisubunit proteases that are found in the cytosol, both
free and attached to the endoplasmic reticulum, and in the nucleus of eukaryotic cells. Their …

We have established high resolution methods for global monitoring of gene expression in
Escherichia coli. Hybridization of radiolabeled cDNA to spot blots on nylon membranes was …

The heat-shock response is a mechanism of cellular protection against sudden adverse
environmental growth conditions and results in the prompt production of various heat-shock …

▪ Abstract Proteolysis by cytoplasmic, energy-dependent proteases plays a critical role in
many regulatory circuits, kee** basal levels of regulatory proteins low and rapidly …