Chronic liver diseases (CLDs) cover a spectrum of liver diseases, ranging from nonalcoholic
fatty liver disease to liver cancer, representing a growing epidemic worldwide with high …

Peritoneal dialysis is an efficient renal replacement therapy for patients with end-stage
kidney disease. However, continuous exposure of the peritoneal membrane to dialysate …

Vascular endothelial cells (ECs) senescence correlates with the increase of cardiovascular
diseases in ageing population. Although ECs rely on glycolysis for energy production, little is …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease characterized by
extensive extracellular matrix (ECM) deposition by activated myofibroblasts, which are …

The accumulation of lactate is a rising risk factor for patients after flap transplantation.
Endothelial‐to‐mesenchymal transition (EndoMT) plays a critical role in skin fibrosis …

Aim Fibrosis is a common pathological feature of most types of chronic liver injuries. There is
no specific treatment for liver fibrosis at present. The liver microenvironment, which fosters …

Hypertrophic scarring is a fibrotic skin disease characterized by excessive deposition of
collagens. Emerging evidence has suggested important roles for peptides in fibrosis-related …

Clinical studies indicate that patients infected with SARS-CoV-2 develop hyperinflammation,
which correlates with increased mortality. The SARS-CoV-2/COVID-19-dependent …

Mitochondrial dysfunction plays an important role in the occurrence and development of
different liver diseases. Oxidative phosphorylation (OXPHOS) dysfunction and production of …

NAD-dependent deacetylase Sirt2 is involved in mammalian metabolic activities, matching
energy demand with energy production and expenditure, and is relevant to a variety of …