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SARS-CoV-2 variant biology: immune escape, transmission and fitness
In late 2020, after circulating for almost a year in the human population, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …
SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks”
An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …
immunity. Knowledge about this interplay can not only help us identify biological …
Heightened innate immune responses in the respiratory tract of COVID-19 patients
Interferon-stimulated genes: what do they all do?
JW Schoggins - Annual review of virology, 2019 - annualreviews.org
In the absence of an intact interferon (IFN) response, mammals may be susceptible to lethal
viral infection. IFNs are secreted cytokines that activate a signal transduction cascade …
viral infection. IFNs are secreted cytokines that activate a signal transduction cascade …
Interstitial macrophages are a focus of viral takeover and inflammation in COVID-19 initiation in human lung
Early stages of deadly respiratory diseases including COVID-19 are challenging to elucidate
in humans. Here, we define cellular tropism and transcriptomic effects of SARS-CoV-2 virus …
in humans. Here, we define cellular tropism and transcriptomic effects of SARS-CoV-2 virus …
Innate immunity in tuberculosis: host defense vs pathogen evasion
CH Liu, H Liu, B Ge - Cellular & molecular immunology, 2017 - nature.com
The major innate immune cell types involved in tuberculosis (TB) infection are
macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells. These immune …
macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells. These immune …
[HTML][HTML] IFITM proteins: Understanding their diverse roles in viral infection, cancer, and immunity
M Gómez-Herranz, J Taylor, RD Sloan - Journal of Biological Chemistry, 2023 - Elsevier
Interferon-induced transmembrane proteins (IFITMs) are broad spectrum antiviral factors that
inhibit the entry of a wide range of clinically important pathogens including influenza A virus …
inhibit the entry of a wide range of clinically important pathogens including influenza A virus …
New insights into the evasion of host innate immunity by Mycobacterium tuberculosis
Q Chai, L Wang, CH Liu, B Ge - Cellular & molecular immunology, 2020 - nature.com
Mycobacterium tuberculosis (Mtb) is an extremely successful intracellular pathogen that
causes tuberculosis (TB), which remains the leading infectious cause of human death. The …
causes tuberculosis (TB), which remains the leading infectious cause of human death. The …