Cellular senescence at the crossroads of inflammation and Alzheimer's disease
Aging is a key risk factor for Alzheimer's disease (AD), but the reasons for this association
are not well understood. Senescent cells accumulate in aged tissues and have been shown …
are not well understood. Senescent cells accumulate in aged tissues and have been shown …
Pericyte control of blood flow across microvascular zones in the central nervous system
The vast majority of the brain's vascular length is composed of capillaries, where our
understanding of blood flow control remains incomplete. This review synthesizes current …
understanding of blood flow control remains incomplete. This review synthesizes current …
Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease
Therapies targeting late events in Alzheimer's disease (AD), including aggregation of
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …
Brain capillary pericytes exert a substantial but slow influence on blood flow
The majority of the brain's vasculature is composed of intricate capillary networks lined by
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …
Vascular contributions to Alzheimer's disease
LB Eisenmenger, A Peret, BM Famakin, A Spahic… - Translational …, 2023 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
progressive neurodegeneration and cognitive decline. Understanding the pathophysiology …
progressive neurodegeneration and cognitive decline. Understanding the pathophysiology …
The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia
Pericyte-mediated capillary constriction decreases cerebral blood flow in stroke after an
occluded artery is unblocked. The determinants of pericyte tone are poorly understood. We …
occluded artery is unblocked. The determinants of pericyte tone are poorly understood. We …
Cells of the blood–brain barrier: an overview of the neurovascular unit in health and disease
The brain is endowed with highly specialized vasculature that is both structurally and
functionally unique compared to vasculature supplying peripheral organs. The blood–brain …
functionally unique compared to vasculature supplying peripheral organs. The blood–brain …
Precapillary sphincters and pericytes at first-order capillaries as key regulators for brain capillary perfusion
Rises in local neural activity trigger local increases of cerebral blood flow, which is essential
to match local energy demands. However, the specific location of microvascular flow control …
to match local energy demands. However, the specific location of microvascular flow control …
Pericyte dysfunction and loss of interpericyte tunneling nanotubes promote neurovascular deficits in glaucoma
Reduced blood flow and impaired neurovascular coupling are recognized features of
glaucoma, the leading cause of irreversible blindness worldwide, but the mechanisms …
glaucoma, the leading cause of irreversible blindness worldwide, but the mechanisms …
Distal activity patterns shape the spatial specificity of neurovascular coupling
É Martineau, A Malescot, N Elmkinssi… - Nature …, 2024 - nature.com
Neurovascular coupling links brain activity to local changes in blood flow, forming the basis
for non-invasive brain map**. Using multiscale imaging, we investigated how vascular …
for non-invasive brain map**. Using multiscale imaging, we investigated how vascular …