Cortisol and major depressive disorder—translating findings from humans to animal models and back
Major depressive disorder (MDD) is a global problem for which current pharmacotherapies
are not completely effective. Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has …
are not completely effective. Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has …
Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness
Rationale Psychosocial stressors are a well-documented risk factor for mental illness.
Neuroinflammation, in particular elevated microglial activity, has been proposed to mediate …
Neuroinflammation, in particular elevated microglial activity, has been proposed to mediate …
Dendritic spine plasticity: function and mechanisms
K Runge, C Cardoso, A De Chevigny - Frontiers in synaptic …, 2020 - frontiersin.org
Dendritic spines are small protrusions studding neuronal dendrites, first described in 1888
by Ramón y Cajal using his famous Golgi stainings. Around 50 years later the advance of …
by Ramón y Cajal using his famous Golgi stainings. Around 50 years later the advance of …
The role of early growth response 1 (EGR1) in brain plasticity and neuropsychiatric disorders
F Duclot, M Kabbaj - Frontiers in behavioral neuroscience, 2017 - frontiersin.org
It is now clearly established that complex interactions between genes and environment are
involved in multiple aspects of neuropsychiatric disorders, from determining an individual's …
involved in multiple aspects of neuropsychiatric disorders, from determining an individual's …
Animal models of major depression and their clinical implications
Major depressive disorder is a common, complex, and potentially life-threatening mental
disorder that imposes a severe social and economic burden worldwide. Over the years …
disorder that imposes a severe social and economic burden worldwide. Over the years …
Sex differences in antidepressant efficacy
Sex differences have been observed across many psychiatric diseases, especially mood
disorders. For major depression, the most prevalent psychiatric disorder, females show a …
disorders. For major depression, the most prevalent psychiatric disorder, females show a …
[HTML][HTML] Understanding stress: Insights from rodent models
Through incorporating both physical and psychological forms of stressors, a variety of rodent
models have provided important insights into the understanding of stress physiology …
models have provided important insights into the understanding of stress physiology …
Long-term effects of chronic stress models in adult mice
I Tran, AK Gellner - Journal of neural transmission, 2023 - Springer
Neuropsychiatric disorders, such as major depression, anxiety disorders, and post-traumatic
stress disorder, tend to be long-term conditions in whose development and maintenance …
stress disorder, tend to be long-term conditions in whose development and maintenance …
Essential role of mesolimbic brain-derived neurotrophic factor in chronic social stress–induced depressive behaviors
Background Previous work has shown that chronic social defeat stress (CSDS) induces
increased phasic firing of ventral tegmental area (VTA) dopamine (DA) neurons that project …
increased phasic firing of ventral tegmental area (VTA) dopamine (DA) neurons that project …
Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK/CREB-mediated histone acetylation
W Fang, J Zhang, L Hong, W Huang, X Dai, Q Ye… - Journal of affective …, 2020 - Elsevier
Background Metformin, a first-line antiglycemic drug, has been reported to have anti-
depressant effects in patients with type 2 diabetes; however, its exact role and underlying …
depressant effects in patients with type 2 diabetes; however, its exact role and underlying …