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Molecular mechanisms of processive glycoside hydrolases underline catalytic pragmatism
Processive and distributive catalysis defines the conversion continuum, thus underpinning
the transformation of oligo-and polymeric substrates by enzymes. Distributive catalysis …
the transformation of oligo-and polymeric substrates by enzymes. Distributive catalysis …
ssDNA accessibility of Rad51 is regulated by orchestrating multiple RPA dynamics
The eukaryotic single-stranded DNA (ssDNA)-binding protein Replication Protein A (RPA)
plays a crucial role in various DNA metabolic pathways, including DNA replication and …
plays a crucial role in various DNA metabolic pathways, including DNA replication and …
Artificial Processive Catalytic Systems
Processive catalysts remain attached to a substrate and perform multiple rounds of catalysis.
They are abundant in nature. This review highlights artificial processive catalytic systems …
They are abundant in nature. This review highlights artificial processive catalytic systems …
PLK1 regulates CtIP and DNA2 interplay in long-range DNA end resection
DNA double-strand break (DSB) repair is initiated by DNA end resection. CtIP acts in short-
range resection to stimulate MRE11–RAD50–NBS1 (MRN) to endonucleolytically cleave …
range resection to stimulate MRE11–RAD50–NBS1 (MRN) to endonucleolytically cleave …
The MRN complex and topoisomerase IIIa–RMI1/2 synchronize DNA resection motor proteins
DNA resection—the nucleolytic processing of broken DNA ends—is the first step of
homologous recombination. Resection is catalyzed by the resectosome, a multienzyme …
homologous recombination. Resection is catalyzed by the resectosome, a multienzyme …
Distinct RPA functions promote eukaryotic DNA replication initiation and elongation
Replication protein A (RPA) binds single-stranded DNA (ssDNA) and serves critical
functions in eukaryotic DNA replication, the DNA damage response, and DNA repair. During …
functions in eukaryotic DNA replication, the DNA damage response, and DNA repair. During …
The canonical RPA complex interacts with Est3 to regulate yeast telomerase activity
CA Moeller-McCoy, TA Wieser, JW Lubin… - Proceedings of the …, 2025 - pnas.org
In most eukaryotic organisms, cells that rely on continuous cell division employ the enzyme
telomerase which replenishes chromosome termini through the addition of telomeric …
telomerase which replenishes chromosome termini through the addition of telomeric …
Targeting CK2-mediated phosphorylation of p53R2 sensitizes BRCA-proficient cancer cells to PARP inhibitors
C Wang, L Tian, Q He, S Lin, Y Wu, Y Qiao, B Zhu, D Li… - Oncogene, 2023 - nature.com
Abstract Poly [ADP-ribose] polymerase (PARP) inhibitors, which selectively kills homologous
recombination (HR) repair-deficient cancer cells, are widely employed to treat cancer …
recombination (HR) repair-deficient cancer cells, are widely employed to treat cancer …
Dna2 removes toxic ssDNA-RPA filaments generated from meiotic recombination-associated DNA synthesis
B Zhai, S Zhang, B Li, J Zhang, X Yang… - Nucleic Acids …, 2023 - academic.oup.com
During the repair of DNA double-strand breaks (DSBs), de novo synthesized DNA strands
can displace the parental strand to generate single-strand DNAs (ssDNAs). Many …
can displace the parental strand to generate single-strand DNAs (ssDNAs). Many …
Cdc13 exhibits dynamic DNA strand exchange in the presence of telomeric DNA
Telomerase is the enzyme that lengthens telomeres and is tightly regulated by a variety of
means to maintain genome integrity. Several DNA helicases function at telomeres, and we …
means to maintain genome integrity. Several DNA helicases function at telomeres, and we …