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Tramadol: understanding the risk of serotonin syndrome and seizures
Tramadol is commonly prescribed for pain control because it presents a lower risk for
addiction and respiratory depression compared to other opioids. However, tramadol's …
addiction and respiratory depression compared to other opioids. However, tramadol's …
Endogenous opiates and behavior: 2005
This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …
the endogenous opioid system, now spanning over a quarter-century of research. It …
The effects of tramadol administration on hippocampal cell apoptosis, learning and memory in adult rats and neuroprotective effects of crocin
Tramadol, a frequently used pain reliever drug, present neurotoxic effects associated to
cognitive dysfunction. Moreover, crocin has been reported to have neuroprotective effects …
cognitive dysfunction. Moreover, crocin has been reported to have neuroprotective effects …
Factors related to seizure in tramadol poisoning and its blood concentration
This study examines the relation between seizure and plasma tramadol concentration in
patients with tramadol poisoning, as a novel centrally acting analgesic used for the treatment …
patients with tramadol poisoning, as a novel centrally acting analgesic used for the treatment …
Preclinical assessment of proconvulsant drug activity and its relevance for predicting adverse events in humans
Safety pharmacology studies, which are performed before first studies with investigational
drugs in humans, often include experiments on proconvulsant drug activity, because such …
drugs in humans, often include experiments on proconvulsant drug activity, because such …
Tramadol poisoning and its management and complications: a sco** review
Background: Tramadol (TR) is an opioid agonist (μ-opioid receptors) that also affects the
noradrenergic and serotonergic systems. TR is a synthetic analgesic substance with opioid …
noradrenergic and serotonergic systems. TR is a synthetic analgesic substance with opioid …
Evidence for the involvement of the dopaminergic system in seizure and oxidative damage induced by tramadol
Tramadol (TR) is a synthetic analgesic drug with central function that can induce seizures
even at therapeutic doses. The exact mechanism of TR effect on seizure generation is not …
even at therapeutic doses. The exact mechanism of TR effect on seizure generation is not …
Tramadol-induced apnea
BACKGROUND AND OBJECTIVES: In contrast with other opioids, there are few cases of
tramadol-related respiratory depression described in the literature, and renal impairment is a …
tramadol-related respiratory depression described in the literature, and renal impairment is a …
Acute tramadol poisoning and its clinical and laboratory findings
Background: Tramadol is a centrally acting analgesic with opioid and nonopioid properties,
which extensively used in the relief of mild to moderate pain. Tramadol poisoning is a …
which extensively used in the relief of mild to moderate pain. Tramadol poisoning is a …
Tramadol-induced seizurogenic effect: a possible role of opioid-dependent histamine (H1) receptor activation-linked mechanism
The present study has been designed to investigate the role of opioid receptors, mast cells,
and histamine receptors (H 1 subtype) in the seizurogenic effect of tramadol on …
and histamine receptors (H 1 subtype) in the seizurogenic effect of tramadol on …