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Breast cancer—epidemiology, risk factors, classification, prognostic markers, and current treatment strategies—an updated review
Simple Summary Breast cancer is the most common cancer among women. It is estimated
that 2.3 million new cases of BC are diagnosed globally each year. Based on mRNA gene …
that 2.3 million new cases of BC are diagnosed globally each year. Based on mRNA gene …
BRCA mutations in ovarian and prostate cancer: bench to bedside
Simple Summary DNA damage is one of the hallmarks of cancer. Epithelial ovarian cancer
(EOC)—especially the high-grade serous subtype—harbors a defect in at least one DNA …
(EOC)—especially the high-grade serous subtype—harbors a defect in at least one DNA …
A population-based study of genes previously implicated in breast cancer
Background Population-based estimates of the risk of breast cancer associated with
germline pathogenic variants in cancer-predisposition genes are critically needed for risk …
germline pathogenic variants in cancer-predisposition genes are critically needed for risk …
Associations between cancer predisposition testing panel genes and breast cancer
Importance Germline pathogenic variants inBRCA1andBRCA2predispose to an increased
lifetime risk of breast cancer. However, the relevance of germline variants in other genes …
lifetime risk of breast cancer. However, the relevance of germline variants in other genes …
Epithelial ovarian cancer: providing evidence of predisposition genes
S Shah, A Cheung, M Kutka, M Sheriff… - International Journal of …, 2022 - mdpi.com
Epithelial ovarian cancer (EOC) is one of the cancers most influenced by hereditary factors.
A fourth to a fifth of unselected EOC patients carry pathogenic variants (PVs) in a number of …
A fourth to a fifth of unselected EOC patients carry pathogenic variants (PVs) in a number of …
Inherited mutations in women with ovarian carcinoma
Importance Germline mutations inBRCA1andBRCA2are relatively common in women with
ovarian, fallopian tube, and peritoneal carcinoma (OC) causing a greatly increased lifetime …
ovarian, fallopian tube, and peritoneal carcinoma (OC) causing a greatly increased lifetime …
Gene-panel sequencing and the prediction of breast-cancer risk
Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins
Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …
breaks in mammalian cells, the defining step of which is homologous strand exchange …
Frequency of germline mutations in 25 cancer susceptibility genes in a sequential series of patients with breast cancer
Purpose Testing for germline mutations in BRCA1/2 is standard for select patients with
breast cancer to guide clinical management. Next-generation sequencing (NGS) allows …
breast cancer to guide clinical management. Next-generation sequencing (NGS) allows …
[HTML][HTML] Genetics of breast cancer: a topic in evolution
S Shiovitz, LA Korde - Annals of Oncology, 2015 - Elsevier
ABSTRACT A hereditary predisposition to breast cancer significantly influences screening
and follow-up recommendations for high-risk women. However, in patients with a suggestive …
and follow-up recommendations for high-risk women. However, in patients with a suggestive …