Skull bone marrow channels as immune gateways to the central nervous system
Decades of research have characterized diverse immune cells surveilling the CNS. More
recently, the discovery of osseous channels (so-called 'skull channels') connecting the …
recently, the discovery of osseous channels (so-called 'skull channels') connecting the …
[HTML][HTML] Niches that regulate stem cells and hematopoiesis in adult bone marrow
S Comazzetto, B Shen, SJ Morrison - Developmental cell, 2021 - cell.com
In mammals, hematopoietic stem cells (HSCs) engage in hematopoiesis throughout adult
life within the bone marrow, where they produce the mature cells necessary to maintain …
life within the bone marrow, where they produce the mature cells necessary to maintain …
A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis
Stromal cells in adult bone marrow that express leptin receptor (LEPR) are a critical source
of growth factors, including stem cell factor (SCF), for the maintenance of haematopoietic …
of growth factors, including stem cell factor (SCF), for the maintenance of haematopoietic …
Lifelong multilineage contribution by embryonic-born blood progenitors
Haematopoietic stem cells (HSCs) arise in the embryo from the arterial endothelium through
a process known as the endothelial-to-haematopoietic transition (EHT),,–. This process …
a process known as the endothelial-to-haematopoietic transition (EHT),,–. This process …
Haematopoietic stem cell self-renewal in vivo and ex vivo
AC Wilkinson, KJ Igarashi, H Nakauchi - Nature Reviews Genetics, 2020 - nature.com
The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood
system homeostasis throughout life and underlies the curative capacity of clinical HSC …
system homeostasis throughout life and underlies the curative capacity of clinical HSC …
Flt3-and Tie2-Cre tracing identifies regeneration in sepsis from multipotent progenitors but not hematopoietic stem cells
In response to infections and stress, hematopoiesis rapidly enhances blood and immune
cell production. The stage within the hematopoietic hierarchy that accounts for this …
cell production. The stage within the hematopoietic hierarchy that accounts for this …
Image-seq: spatially resolved single-cell sequencing guided by in situ and in vivo imaging
Tissue function depends on cellular organization. While the properties of individual cells are
increasingly being deciphered using powerful single-cell sequencing technologies …
increasingly being deciphered using powerful single-cell sequencing technologies …
Endothelial and leptin receptor+ cells promote the maintenance of stem cells and hematopoiesis in early postnatal murine bone marrow
Mammalian hematopoietic stem cells (HSCs) colonize the bone marrow during late fetal
development, and this becomes the major site of hematopoiesis after birth. However, little is …
development, and this becomes the major site of hematopoiesis after birth. However, little is …
Stem cell quiescence: the challenging path to activation
N Urbán, TH Cheung - Development, 2021 - journals.biologists.com
Quiescence is a cellular state in which a cell remains out of the cell cycle but retains the
capacity to divide. The unique ability of adult stem cells to maintain quiescence is crucial for …
capacity to divide. The unique ability of adult stem cells to maintain quiescence is crucial for …
Heterogeneous anomalous transport in cellular and molecular biology
TA Waigh, N Korabel - Reports on Progress in Physics, 2023 - iopscience.iop.org
It is well established that a wide variety of phenomena in cellular and molecular biology
involve anomalous transport eg the statistics for the motility of cells and molecules are …
involve anomalous transport eg the statistics for the motility of cells and molecules are …