The cytoprotective role of the Keap1–Nrf2 pathway
An elaborate network of highly inducible proteins protects aerobic cells against the
cumulative damaging effects of reactive oxygen intermediates and toxic electrophiles, which …
cumulative damaging effects of reactive oxygen intermediates and toxic electrophiles, which …
Regulation of glutathione synthesis
Glutathione (GSH) is a ubiquitous intracellular peptide with diverse functions that include
detoxification, antioxidant defense, maintenance of thiol status, and modulation of cell …
detoxification, antioxidant defense, maintenance of thiol status, and modulation of cell …
Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene
J Alam, D Stewart, C Touchard, S Boinapally… - Journal of Biological …, 1999 - ASBMB
Stress response elements, which mediate induction of the mouse heme oxygenase-1 (HO-1)
gene by several agents, resemble the binding site for the activator protein-1 (Jun/Fos), Maf …
gene by several agents, resemble the binding site for the activator protein-1 (Jun/Fos), Maf …
Regulatory mechanisms controlling gene expression mediated by the antioxidant response element
T Nguyen, PJ Sherratt, CB Pickett - Annual review of …, 2003 - annualreviews.org
The expression of genes encoding antioxidative and Phase II detoxification enzymes is
induced in cells exposed to electrophilic compounds and phenolic antioxidants. Induction of …
induced in cells exposed to electrophilic compounds and phenolic antioxidants. Induction of …
Regulation of gene expression by reactive oxygen
TP Dalton, HG Shertzer, A Puga - Annual review of …, 1999 - annualreviews.org
▪ Abstract Reactive oxygen intermediates are produced in all aerobic organisms during
respiration and exist in the cell in a balance with biochemical antioxidants. Excess reactive …
respiration and exist in the cell in a balance with biochemical antioxidants. Excess reactive …
Small Maf proteins (MafF, MafG, MafK): history, structure and function
The small Maf proteins (sMafs) are basic region leucine zipper (bZIP)-type transcription
factors. The basic region of the Maf family is unique among the bZIP factors, and it …
factors. The basic region of the Maf family is unique among the bZIP factors, and it …
Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells
In Saccharomyces cerevisiae, chemical or genetic inhibition of proteasome activity induces
new proteasome synthesis promoted by the transcription factor RPN4. This ensures that …
new proteasome synthesis promoted by the transcription factor RPN4. This ensures that …
Inhibition of NGLY1 inactivates the transcription factor Nrf1 and potentiates proteasome inhibitor cytotoxicity
Proteasome inhibitors are used to treat blood cancers such as multiple myeloma (MM) and
mantle cell lymphoma. The efficacy of these drugs is frequently undermined by acquired …
mantle cell lymphoma. The efficacy of these drugs is frequently undermined by acquired …
[HTML][HTML] Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1
K Ogawa, J Sun, S Taketani, O Nakajima… - The EMBO …, 2001 - embopress.org
Heme controls expression of genes involved in the synthesis of globins and heme. The
mammalian transcription factor Bach1 functions as a repressor of the Maf recognition …
mammalian transcription factor Bach1 functions as a repressor of the Maf recognition …
[HTML][HTML] Overlooked and valuable facts to know in the NRF2/KEAP1 field
NRF2 (nuclear factor erythroid 2-related factor 2) is a critical regulator of the cellular stress
response. It is a transcription factor that controls the expression of hundreds of genes. We …
response. It is a transcription factor that controls the expression of hundreds of genes. We …