Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has
remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated …

Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD,
Myogenin and MRF4 was a seminal step in understanding specification of the skeletal …

Skeletal muscle has remarkable regeneration capabilities, mainly due to its resident muscle
stem cells (MuSCs). In this review, we introduce recently developed technologies and the …

Muscle regeneration requires the coordinated interaction of multiple cell types. Satellite cells
have been implicated as the primary stem cell responsible for regenerating muscle, yet the …

Skeletal muscles are essential for vital functions such as movement, postural support,
breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic …

Skeletal muscle tissue provides mechanical force for locomotion of all vertebrate animals. It
is prone to damage from acute physical trauma and physiological stress. To cope with this, it …

Following their discovery in 1961, it was speculated that satellite cells were dormant
myoblasts, held in reserve until required for skeletal muscle repair. Evidence for this …

Muscle wasting and cachexia have long been postulated to be key determinants of cancer-
related death, but there has been no direct experimental evidence to substantiate this …

Distinct cell populations with regenerative capacity have been reported to contribute to
myofibres after skeletal muscle injury, including non-satellite cells as well as myogenic …

We discuss the upstream regulators of myogenesis that lead to the activation of myogenic
determination genes and subsequent differentiation, focusing on the mouse model. Key …